The following highways are numbered 2. For roads numbered A2, see list of A2 roads. For roads numbered B2, see list of B2 roads. For roads numbered M2, see list of M2 roads. For roads numbered N2, see list of N2 roads.

International

• AH2 Asian Highway 2, an international road from Indonesia to Iran
• E2 European route E2
• E002 European route E002
• Trans-Sahara Highway

Africa

Congo, Democratic Republic of the

• National Road 2 (Democratic Republic of the Congo)

Djibouti

• RN-2 (Djibouti)

Nigeria

• Nigeria Trunk Road A2

South Africa

• N2 road (South Africa)
• M2 (Johannesburg)
• M2 (Pretoria)

Senegal

• N2 road (Senegal)

Tanzania

• T2 road (Tanzania)

Zambia

• T2 road (Zambia)
• M2 road (Zambia)

Asia

Bangladesh

• N2 – Dhaka–Sylhet Highway

Burma

• National Highway 2 (Burma)

Cambodia

• National Highway 2 (Cambodia)

China

• G2 Expressway

Hong Kong

• Route 2 (Hong Kong)

India

• National Highway 2 (India)
• State Highway 2 (Rajasthan)
• State Highway 2 (Andhra Pradesh)
• State Highway 2 (West Bengal)

Indonesia

• Indonesian National Route 2

Iran

• Freeway 2 (Iran)

Iraq

• Highway 2 (Iraq)

Israel

• Highway 2 (Israel)

Japan

• National Route 2
• San'yō Expressway
  • Chūgoku Expressway
  • Kanmon Bridge
• Route 2 (Shuto Expressway) in Tokyo
• Route 2 (Nagoya Expressway)
• Route 2 (Hanshin Expressway) in Osaka

Korea, South

• National Route 2

Malaysia

• FT 2 Malaysia Federal Route 2

Oman

• Route 2 (Oman)

Pakistan

• M-2 motorway (Pakistan)

Philippines

• C-2 Circumferential Road 2
• R-2 Radial Road 2
• N2 highway (Philippines)
• E2 expressway (Philippines)

Sri Lanka

•  A2  Galle Road
•  E02  Colombo Inter-provincial Orbital Router

Taiwan

• Freeway 2 (Taiwan)
• Provincial Highway 2 (Taiwan)

Thailand

• Thailand Route 2 (Mittraphap Road)

Turkey

• O-2, a motorway in Turkey as the outer half ring road in Istanbul.

Europe

Albania

• SH-2 Highway in Albania from Tirana to Durrës.

Austria

• Süd Autobahn

Belarus

• M2 highway (Belarus)

Belgium

• R2 road (Belgium)

Bulgaria

• Републикански път I-2/Route 2 (I-2/E70)
• Автомагистрала „Хемус“ (A2/E73/E83/E772)

Czech Republic

• D2 from Brno to Bratislava in Slovakia
• I/2 Highway (in Czech)

Finland

• Finnish national road 2
• Åland Islands Highway 2

France

• Route nationale 2

Germany

• Bundesautobahn 2
• Bundesstraße 2

Greece

• Εθνική Οδός 2 (EO2)
• Εγνατία Οδός (A2/E90)

Hungary

• M2 expressway (Hungary)
• Main road 2 (Hungary)

Ireland

• M2 motorway (Republic of Ireland)
• N2 road (Ireland)

Italy

• Autostrada A2
• Autostrada A2 (old)
• RA 2
• T2
• State road 2

Moldova

• National Road 2 (R2)
  • M2 highway (M2/E584) is a national road with highway status. This route leaves Chișinău, via Orhei and the route arrives at Soroca, on the border with Ukraine

Netherlands

• Rijksweg 2

Poland

• National road 2 (DK2)
• Motorway of Freedom (A2/E30)
• expressway S2, Southern Warsaw Bypass

Portugal

• A2 motorway (Portugal)

Romania

• National Road 2 (DN2/E58/E60/E85/E583)
  • DN2A
  • DN2B
• Autostrada Soarelui (A2/E81)

Russia

• M2 highway (Russia)

United Kingdom

• M2 motorway (Great Britain)
• A2 road (England)
• M2 motorway (Northern Ireland)
• A2 road (Northern Ireland)

Ukraine

• Highway M02 (Ukraine)

North America

Canada

• Alberta Highway 2 (including the Queen Elizabeth II Highway)
• British Columbia Highway 2
• Manitoba Highway 2
• New Brunswick Route 2 (part of the Trans-Canada Highway)
• Newfoundland and Labrador Route 2
• Northwest Territories Highway 2
• Nova Scotia Trunk 2
• Ontario Highway 2 (almost entirely removed from the network)
• Prince Edward Island Route 2
• Quebec Route 2 (former)
• Saskatchewan Highway 2
• Yukon Highway 2

Costa Rica

• National Route 2

Dominican Republic

• DR-2

Mexico

• Mexican Federal Highway 2

United States

• Interstate 2
• Interstate A-2 (Alaska; unsigned)
• Interstate H-2 (Hawaii)
• U.S. Route 2
  • U.S. Route 2N (former)
  • U.S. Route 2S (former)
• New England Interstate Route 2 (former)
• Alabama State Route 2
• Alaska Route 2
• Arkansas Highway 2 (former)
• California State Route 2
• Colorado State Highway 2
• Connecticut Route 2
• Delaware Route 2
• Florida State Road 2
  • County Road 2 (Nassau County, Florida)
  • County Road 2 (Okaloosa County, Florida)
    • County Road 2B (Okaloosa County, Florida)
  • County Road 2 (Walton County, Florida)
• Georgia State Route 2
• Illinois Route 2
• Indiana State Road 2
• Iowa Highway 2
• K-2 (Kansas highway)
• Kentucky Route 2
• Louisiana Highway 2
  • Louisiana State Route 2 (former)
• Maryland Route 2
• Massachusetts Route 2
• County Road 2 (Goodhue County, Minnesota)
  • County Road 2 (Hennepin County, Minnesota)
  • County Road 2 (Pine County, Minnesota)
  • County Road 2 (Scott County, Minnesota)
  • County Road 2 (Washington County, Minnesota)
• Mississippi Highway 2
• Missouri Route 2
  • Missouri Route 2 (1922) (former)
• Montana Highway 2
• Nebraska Highway 2
  • Nebraska Spur 2B
  • Nebraska Recreation Road 2D
• Nevada State Route 2 (former)
  • Nevada State Route 2B (former)
  • Nevada State Route 2C (former)
• New Jersey Route 2 (former)
  • New Jersey Route 2N (former)
  • County Route 2 (Monmouth County, New Jersey)
• New Mexico State Road 2
• New York State Route 2
  • County Route 2 (Allegany County, New York)
  • County Route 2 (Chemung County, New York)
  • County Route 2 (Chenango County, New York)
  • County Route 2 (Clinton County, New York)
  • County Route 2 (Columbia County, New York)
  • County Route 2 (Delaware County, New York)
  • County Route 2 (Dutchess County, New York)
  • County Route 2 (Erie County, New York)
  • County Route 2 (Essex County, New York)
  • County Route 2 (Franklin County, New York)
  • County Route 2 (Genesee County, New York)
  • County Route 2 (Lewis County, New York)
  • County Route 2 (Madison County, New York)
  • County Route 2 (Monroe County, New York)
  • County Route 2 (Nassau County, New York)
  • County Route 2 (Niagara County, New York)
  • County Route 2 (Oneida County, New York)
  • County Route 2 (Onondaga County, New York)
  • County Route 2 (Ontario County, New York)
  • County Route 2 (Oswego County, New York)
  • County Route 2 (Rensselaer County, New York)
  • County Route 2 (Steuben County, New York)
  • County Route 2 (Suffolk County, New York)
  • County Route 2 (Washington County, New York)
  • County Route 2 (Yates County, New York)
• North Carolina Highway 2
• Ohio State Route 2
• Oklahoma State Highway 2
• Oregon Route 2 (former)
• Pennsylvania Route 2 (former)
• Rhode Island Route 2
• South Carolina Highway 2
• Tennessee State Route 2
• Texas State Highway 2 (former)
  • Texas State Highway Loop 2
  • Farm to Market Road 2
  • Texas Park Road 2
  • Texas Recreational Road 2
• Utah State Route 2 (former)
• Vermont Route 2B
• Virginia State Route 2
• Washington State Highway 2 (former)
• West Virginia Route 2

Territories

• Guam Highway 2
• Interstate PR-2 (unsigned)
• Puerto Rico Highway 2
  • Puerto Rico Highway 2R

South America

Argentina

• Buenos Aires Provincial Route 2

Paraguay

• National Route 2

Peru

• Peru Highway 2

Uruguay

• Route 2 Grito de Asencio

Oceania

Australia

New South Wales

• M2 Hills Motorway
• Lane Cove Tunnel
• Windsor Road (Sydney)
• Gold Coast Highway (Queensland, New South Wales)

Northern Territory

(future ) Namatjira Drive

Queensland

• 
  • Ipswich Motorway (Brisbane)
  • Warrego Highway (Brisbane)
• 
  • Logan Motorway (Brisbane)
  • Gateway Motorway (Brisbane)
• Warrego ( Toowoomba Bypass), Landsborough, and Barkly Highways (Queensland)
• Warrego and Mitchell Highway
• Gold Coast Highway (Queensland, New South Wales)
• Brisbane

South Australia

• 
  • Southern Expressway
  • North–South Motorway
  • Northern Expressway
• 
  • South Road, Adelaide

Tasmania

• Bass Highway, Tasmania

Victoria

• Tullamarine Freeway (Melbourne)
• CityLink Tolled Freeway

Western Australia

• State Route 2 (Western Australia) – Mitchell Freeway, Kwinana Freeway, and Forrest Highway

New Zealand

• New Zealand State Highway 2