The following highways are numbered 59:
Interstate 59
U.S. Route 59
Alabama State Route 59
Arkansas Highway 59
California State Route 59
Colorado State Highway 59
Connecticut Route 59
Florida State Road 59
Georgia State Route 59
Illinois Route 59
Indiana State Road 59
Kentucky Route 59
Louisiana Highway 59
Maryland Route 59 (former)
M-59 (Michigan highway)
Missouri Route 59
Montana Highway 59
Nebraska Highway 59
Nevada State Route 59 (former) New Jersey Route 59
New Mexico State Road 59
New York State Route 59
County Route 59 (Chautauqua County, New York)
County Route 59 (Dutchess County, New York)
County Route 59 (Herkimer County, New York) County Route 59 (Jefferson County, New York) County Route 59 (Madison County, New York) County Route 59 (Orange County, New York) County Route 59 (Oswego County, New York)
County Route 59 (Putnam County, New York)
County Route 59 (Rensselaer County, New York) County Route 59 (Schoharie County, New York) County Route 59 (St. Lawrence County, New York) County Route 59 (Steuben County, New York)
County Route 59 (Suffolk County, New York)
County Route 59 (Sullivan County, New York)
County Route 59 (Washington County, New York) County Route 59 (Wyoming County, New York)
North Carolina Highway 59 (former).svg){kind=small}
North Dakota Highway 59
Ohio State Route 59
Oklahoma State Highway 59
Pennsylvania Route 59
South Carolina Highway 59
South Dakota Highway 59 (former)
Tennessee State Route 59
Texas State Highway 59
Utah State Route 59
Virginia State Route 59
West Virginia Route 59
Wisconsin Highway 59
Wyoming Highway 59
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