The following highways are numbered 72:
Interstate 72
U.S. Route 72
Alabama State Route 72
Arizona State Route 72
Arkansas Highway 72
California State Route 72
Colorado State Highway 72
Connecticut Route 72
Delaware Route 72
Florida State Road 72
Georgia State Route 72
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Georgia State Route 72 (1930–1941) (former)
Hawaii Route 72
Idaho State Highway 72
Illinois Route 72
Kentucky Route 72
Louisiana Highway 72
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Louisiana State Route 72 (former)
Maryland Route 72 (former)
M-72 (Michigan highway)
Minnesota State Highway 72
Missouri Route 72
Montana Highway 72
Nebraska Highway 72 (former)
Nevada State Route 72 (former) New Jersey Route 72
New Mexico State Road 72
New York State Route 72
County Route 72 (Cattaraugus County, New York)
County Route 72 (Chautauqua County, New York)
County Route 72 (Dutchess County, New York)
County Route 72 (Essex County, New York) County Route 72 (Jefferson County, New York)
County Route 72 (Livingston County, New York) County Route 72 (Madison County, New York) County Route 72 (Montgomery County, New York)
County Route 72 (Orange County, New York)
County Route 72 (Putnam County, New York)
County Route 72 (Rockland County, New York)
County Route 72 (Suffolk County, New York)
North Carolina Highway 72
Ohio State Route 72
Oklahoma State Highway 72
Oklahoma State Highway 72 (1930s) (former)
Pennsylvania Route 72
South Carolina Highway 72
Tennessee State Route 72
Texas State Highway 72
Utah State Route 72
Virginia State Route 72
West Virginia Route 72
Wisconsin Highway 72
Wyoming Highway 72 U.S. Virgin Islands Highway 72
