This is a list of the largest cities of the Mexican state of Jalisco, based on the population of the cities, not including the municipalities' total population.

Rank	City	Population	Municipality	Description
1	Guadalajara	1,500,800	Guadalajara	Guadalajara is Mexico's second largest city. It serves as the capital of Jalisco, and is also a growing metropolis of western Mexico. A city devoted to modern technology and distinctive architecture, Guadalajara is the 10 largest city in Latin America by population.
2	Zapopan	1,202,900	Zapopan	Zapopan is one of the prosperous cities conjoining Guadalajara, it is known as the new home for the soccer team Chivas' new stadium, Estadio Omnilife.
3	Tlaquepaque	605,000	Tlaquepaque	Tlaquepaque is a city enclaved within the extensive metropolis of Guadalajara. It is known for its clay pottery and blown glass. Colorful festivities and admiring chapels bring flare to Tlaquepaque.
4	Tonalá	440,800	Tonalá	Tonalá has its nickname of Cuna alfarera, or "Cradle of Pottery", because of its dedication to pottery, since many centuries.
5	Puerto Vallarta	221,200	Puerto Vallarta	Puerto Vallarta is a seaside resort town off the coast of the Pacific Ocean's Bahía de Banderas. The city's population has boomed since 2000. Vallarta is a city with Spanish-tile roofed houses contrasting the blue ocean.
6	Lagos de Moreno	104,500	Lagos de Moreno	Lagos de Moreno is called by Mexicans, with some hyperbole, the "Athens of Jalisco" because of the numerous writers and poets who were born there. Important industries include food processing, including milk and dairy products, vegetable oils, and meats, manufacture of footwear and agricultural machinery. At the 2010 census the city had a population of 153,817 inhabitants, making it the 6th largest city in the state of Jalisco.
7	Tepatitlán de Morelos	98,100	Tepatitlán de Morelos
8	Ciudad Gúzman	97,750	Zapotlán el Grande
9	Hacienda Santa Fe	86,935	Tlajomulco de Zúñiga
10	Ocotlán	83,769	Ocotlán
11	Tesistán	62,397	Zapopan
12	Arandas	52,175	Arandas