The highest-selling digital singles in the United States are ranked in the Hot Digital Songs chart, published by Billboard magazine. The data are compiled by Nielsen SoundScan based on each single's weekly digital sales, which combines sales of different versions of a single for a summarized figure.
| † | Indicates best-charting digital song of 2012[1] |
| Issue date | Song | Artist(s) | Weekly sales | Ref(s) |
|---|---|---|---|---|
| January 7 | "Sexy and I Know It" | LMFAO | 395,000 | [2][3] |
| January 14 | 417,000 | [4][5] | ||
| January 21 | "I Won't Give Up" | Jason Mraz | 229,000 | [6][7] |
| January 28 | "Set Fire to the Rain" | Adele | 193,000 | [8][9] |
| February 4 | "Turn Me On" | David Guetta featuring Nicki Minaj | 198,000 | [10][11] |
| February 11 | "Stronger (What Doesn't Kill You)" | Kelly Clarkson | 225,000 | [12][13] |
| February 18 | 237,000 | [14][15] | ||
| February 25 | "We Are Young" | Fun featuring Janelle Monáe | 296,000 | [16][17] |
| March 3 | "Part of Me" | Katy Perry | 411,000 | [18][19] |
| March 10 | "We Are Young" | Fun featuring Janelle Monáe | 291,000 | [20][21] |
| March 17 | 302,000 | [22][23] | ||
| March 24 | 322,000 | [24][25] | ||
| March 31 | 349,000 | [26][27] | ||
| April 7 | 387,000 | [28][29] | ||
| April 14 | "Boyfriend" | Justin Bieber | 521,000 | [30][31] |
| April 21 | "We Are Young" | Fun featuring Janelle Monáe | 390,000 | [32][33] |
| April 28 | "Somebody That I Used to Know" † | Gotye featuring Kimbra | 542,000 | [34][35] |
| May 5 | "Payphone" | Maroon 5 featuring Wiz Khalifa | 493,000 | [36][37] |
| May 12 | "Somebody That I Used to Know" | Gotye featuring Kimbra | 414,000 | [38][39] |
| May 19 | 348,000 | [40][41] | ||
| May 26 | 321,000 | [42][43] | ||
| June 2 | "Call Me Maybe" | Carly Rae Jepsen | 293,000 | [44][45] |
| June 9 | 301,000 | [46][47] | ||
| June 16 | 284,000 | [48][49] | ||
| June 23 | 296,000 | [50][51] | ||
| June 30 | 292,000 | [52][53] | ||
| July 7 | 263,000 | [54][55] | ||
| July 14 | 251,000 | [56][57] | ||
| July 21 | 244,000 | [58][59] | ||
| July 28 | "Wide Awake" | Katy Perry | 205,000 | [60][61] |
| August 4 | "Whistle" | Flo Rida | 211,000 | [62][63] |
| August 11 | 237,000 | [64][65] | ||
| August 18 | "Home" | Phillip Phillips | 228,000 | [66][67] |
| August 25 | "Whistle" | Flo Rida | 217,000 | [68][69] |
| September 1 | "We Are Never Ever Getting Back Together" | Taylor Swift | 623,000 | [70][71] |
| September 8 | 307,000 | [72][73] | ||
| September 15 | 253,000 | [74][75] | ||
| September 22 | 284,000 | [76][77] | ||
| September 29 | 226,000 | [78][79] | ||
| October 6 | "Gangnam Style" | Psy | 301,000 | [80][81] |
| October 13 | "Begin Again" | Taylor Swift | 299,000 | [82][83] |
| October 20 | "Live While We're Young" | One Direction | 341,000 | [84][85] |
| October 27 | "I Knew You Were Trouble" | Taylor Swift | 416,000 | [86][87] |
| November 3 | "Gangnam Style" | Psy | 229,000 | [88][89] |
| November 10 | 255,000 | [90][91] | ||
| November 17 | 226,000 | [92][93] | ||
| November 24 | 187,000 | [94][95] | ||
| December 1 | "Diamonds" | Rihanna | 171,000 | [96][97] |
| December 8 | "Gangnam Style" | Psy | 229,000 | [98][99] |
| December 15 | "Scream & Shout" | will.i.am featuring Britney Spears | 196,000 | [100][101] |
| December 22 | "Locked Out of Heaven" | Bruno Mars | 197,000 | [102][103] |
| December 29 | 222,000 | [104][105] |