This is a list of the number-one hits of 2010 on FIMI's Italian Singles and Albums Charts.
| Issue date | Song | Artist | Album | Artist |
|---|---|---|---|---|
| 4 January | "Bad Romance" | Lady Gaga | Tracks 2 (inediti & rarità) | Vasco Rossi |
| 11 January | "Baciami ancora" | Jovanotti | ||
| 18 January | ||||
| 25 January | ||||
| 1 February | Soldier of Love | Sade | ||
| 8 February | ||||
| 15 February | "Per tutta la vita" | Noemi | Re matto | Marco Mengoni |
| 22 February | "Per tutte le volte che..." | Valerio Scanu | ||
| 1 March | "Baciami ancora" | Jovanotti | ||
| 8 March | "Per tutta la vita" | Noemi | ||
| 15 March | "Each Tear" | Mary J. Blige featuring Tiziano Ferro | Oltre | Emma Marrone |
| 22 March | "Di notte" | Pierdavide Carone | ||
| 29 March | "Calore" | Emma Marrone | Una canzone pop | Pierdavide Carone |
| 5 April | ||||
| 12 April | "Un colpo all'anima" | Ligabue | Inaspettata | Biagio Antonacci |
| 19 April | ||||
| 26 April | ||||
| 3 May | "Alors on danse" | Stromae | ||
| 10 May | "Quello che dai" | Marco Carta | Arrivederci, mostro! | Ligabue |
| 17 May | "Waka Waka (This Time for Africa)" | Shakira featuring Freshlyground | ||
| 24 May | ||||
| 31 May | ||||
| 7 June | Semplicemente sei | Gigi D'Alessio | ||
| 14 June | Arrivederci, mostro! | Ligabue | ||
| 21 June | Vasco London Instant Live 04.05.2010 | Vasco Rossi | ||
| 28 June | ||||
| 5 July | ||||
| 12 July | Arrivederci, mostro! | Ligabue | ||
| 19 July | ||||
| 26 July | ||||
| 2 August | She Wolf | Shakira | ||
| 9 August | ||||
| 16 August | The Final Frontier | Iron Maiden | ||
| 23 August | ||||
| 30 August | ||||
| 6 September | "Love the Way You Lie" | Eminem featuring Rihanna | Controcultura | Fabri Fibra |
| 13 September | "White Knuckle Ride" | Jamiroquai | A Thousand Suns | Linkin Park |
| 20 September | "Love the Way You Lie" | Eminem featuring Rihanna | Wonderlustre | Skunk Anansie |
| 27 September | "Loca" | Shakira featuring Dizzee Rascal | Il mondo in un secondo | Alessandra Amoroso |
| 4 October | ||||
| 11 October | ||||
| 18 October | Re matto live | Marco Mengoni | ||
| 25 October | Sale el Sol | Shakira | ||
| 1 November | Chocabeck | Zucchero | ||
| 8 November | "Only Girl (In the World)" | Rihanna | ||
| 15 November | "The Time (Dirty Bit)" | The Black Eyed Peas | Casa 69 | Negramaro |
| 22 November | "In punta di piedi" | Nathalie | ||
| 29 November | "Tutto l'amore che ho" | Jovanotti | Arrivederci, mostro! | Ligabue |
| 6 December | Michael | Michael Jackson | ||
| 13 December | ||||
| 20 December | Chocabeck | Zucchero | ||
| 27 December | Michael | Michael Jackson |