The following is a partial list of notable residents, past and present, from Eugene, Oregon, United States. A separate list of people from Oregon is available.

Artists

• Maude Kerns, artist
• Taravat Talepasand, artist
• Olga Volchkova, cast-glass sculptor, icon painter

Athletes

• Danny Ainge, North Eugene High School (1977), NBA player, coach and team executive
• Jon Anderson, Olympian, 1973 Boston Marathon winner
• Alex Brink, Canadian Football League quarterback^[1]
• Gregory Byrne, athletics director at Mississippi State University
• Todd Christensen, Sheldon High School (1974), Los Angeles Raiders NFL tight end
• Brian Conklin, professional basketball player for Limoges CSP of the LNB Pro A
• Mary Decker, middle-distance runner, two-time world champion, member of National Track and Field Hall of Fame
• Bill Dellinger, middle-distance runner and University of Oregon coach, Olympic bronze medalist
• Ashton Eaton, decathlete, five-time world champion, two-time Olympic gold medalist^[2]
• Tim Euhus, Churchill High School, NFL tight end
• Dan Fouts, University of Oregon (1970–72), San Diego Chargers (NFL) quarterback, Pro Football Hall of Famer, TV commentator
• Joey Harrington, University of Oregon (1998–2001), NFL quarterback
• Jamey Harris, 1998 national champion, 1,500 meters
• Justin Herbert, Sheldon High School (Oregon), University of Oregon (2016–19), Los Angeles Chargers (NFL) quarterback, Rose Bowl MVP
• Cyrus Hostetler, javelin thrower, Pan American Games silver medalist^[3]
• Luke Jackson, University of Oregon, NBA player, basketball coach at Northwest Christian University
• Nate Jaqua, South Eugene High School (2000), Seattle Sounders striker
• Jordan Kent, Churchill High School, University of Oregon three-sport star, son of UO coach Ernie Kent, wide receiver Seattle Seahawks (NFL)
• Matt LaBounty, Oregon, 49ers, Packers, and Seahawks NFL defensive end
• Keith Lewis, University of Oregon, San Francisco 49ers free safety
• Marcus Mariota, University of Oregon (2012–14), Heisman Trophy Winner, Tennessee Titans quarterback (2015–19), Las Vegas Raiders quarterback (2020–present)
• Casey Martin, professional golfer, University of Oregon golf coach
• Bill McChesney, University of Oregon distance runner, 1980 Olympic team member
• Quintin Mikell, Willamette High School, Philadelphia Eagles (NFL) defensive back
• Chris Miller, Sheldon High School (1983), University of Oregon (1983–86), NFL quarterback
• Kenny Moore, North Eugene High School (1962), University of Oregon (1963–66), runner, Olympic marathoner, sportswriter (Sports Illustrated), screenwriter (Without Limits), author (Bowerman and the Men of Oregon), actor in track movie Personal Best
• Haloti Ngata, University of Oregon (2006), Baltimore Ravens, Detroit Lions (NFL) defensive tackle
• Aaron Olson, professional cyclist
• Steve Prefontaine, University of Oregon (1973), Olympic runner
• Jeff Quinney, 2000 U.S. amateur golf champion, PGA player
• Ahmad Rashad (formerly Bobby Moore), University of Oregon football player (1969–71), NFL receiver, NBC sportscaster
• Dathan Ritzenhein, distance runner, 2008 USA men's Olympic marathon team
• Marla Runyan, distance runner, five-time Paralympic Games gold medalist
• Alberto Salazar, distance runner, marathoner, coach until he was banned for life
• Onterrio Smith, University of Oregon, NFL running back
• David Vobora, Churchill High School, NFL linebacker
• Josh Wilcox, University of Oregon, NFL tight end
• Kailee Wong, North Eugene High School, NFL linebacker

Authors

• David Bischoff, science fiction author
• Richard Brautigan, author
• George Hitchcock (1914–2010), poet and publisher of the literary journal Kayak^[4]
• Nina Kiriki Hoffman, author
• Ken Kesey, author
• Damon Knight, author
• Grace Llewellyn, author of The Teenage Liberation Handbook
• Laurie Notaro, author
• Jerry Oltion, author, astronomer, and inventor
• Chuck Palahniuk, author
• Casey Plett, writer
• Bruce Holland Rogers, author
• William L. Sullivan, author of outdoor guide books
• John Varley, science fiction author
• Ray Vukcevich, fantasy and literary author
• Bob Welch, author, columnist for The Register-Guard
• Leslie What, author
• Kate Wilhelm, author
• Anthony Wynn, author

Entertainment

• Andy Andrist, comedian
• Brandon Beemer, actor
• Dan Carlin, podcaster and author
• Esther K. Chae, actress
• William De Los Santos, screenwriter for 2002 Eugene-based film Spun
• Demetri Goritsas, actor
• Howard Hesseman, actor
• Christopher Judge, actor (Stargate SG-1), as Doug Judge; football star at the University of Oregon in the mid-1980s
• Rose McGowan, actress, grew up in Eugene^[5]
• Austin O'Brien, actor, costarred with Arnold Schwarzenegger in Last Action Hero as well as appearing in many other films and TV shows
• Eric Christian Olsen, actor
• Rebecca Schaeffer, actress in My Sister Sam
• David Ogden Stiers, actor on the television series M*A*S*H; was in the first graduating class of North Eugene High School (1960)
• Eric A. Stillwell, screenwriter and producer
• Caitlin Wachs, actress
• Jenny Wade, actress, Churchill High School alumnus
• Craig Wasson, actor
• Puddles the Duck, mascot, dancer
• Bryce Zabel, Hollywood writer and producer; chairman Academy of Television Arts & Sciences

Music

• Frank Black, musician, Pixies singer and guitarist
• Tracy Bonham, musician
• Isaac Brock, musician, Modest Mouse, Ugly Casanova
• Andie Case, musician
• Robert Cray, musician
• Anna Gilbert, musician
• Tim Hardin, musician
• Megan Marie Hart, operatic soprano
• Evynne Hollens, musician
• Peter Hollens, musician
• Kelly Keagy, musician (drummer for Night Ranger)
• Mat Kearney, musician
• Daniel Levitin, neuroscientist, author, musician, attended University of Oregon 1992–1996
• Mark Lindsay, musician, lead singer of Paul Revere and the Raiders
• Halie Loren, singer-songwriter
• Courtney Love, frontwoman of alternative rock band Hole, lived in Eugene as a child with her mother
• Shawn McDonald, musician
• Frank Navetta (1962–2008), original bassist for punk band Descendents; born in California, moved to Eugene in 1985 and lived there until his death
• Steve Perry, musician, lead singer, songwriter Cherry Poppin' Daddies
• RJD2, music producer, singer and musician
• Rock and Roll Soldiers, band
• Curtis Salgado, Willamette High School alumnus (1971), blues musician
• Dan Schmid, musician, Cherry Poppin' Daddies/Frank Black bassist
• Corin Tucker, musician, Sleater-Kinney
• Theresa Becker Wayman, musician; singer-songwriter; actor; guitarist and vocalist of the indie rock band Warpaint
• Mason Williams, musician, writer
• Paul Wright, musician
• Michelle Zauner, musician, lead vocalist and songwriter for Japanese Breakfast; author of her memoir, Crying in H Mart

Others

• Garner Ted Armstrong, radio and television evangelist
• Herbert W. Armstrong, evangelist and author
• John Brombaugh, pipe organ builder
• Edgar Buchanan, dentist, actor
• Robert Lee Burns, reformed convict
• James Dutton, U.S. Air Force test pilot and NASA astronaut
• Neil Goldschmidt, politician, Mayor of Portland, U.S. Secretary of Transportation
• Jacob Hacker, political scientist
• Creed C. Hammond, Major General and Chief of the National Guard Bureau^[6]
• Jack Herer, cannabis activist, author^[7]
• Terri Irwin, naturalist, wife of Crocodile Hunter Steve Irwin
• Phil Knight, co-founder of Nike, Inc.
• Eugene Lazowski, Polish physician, saved 8,000 people by creating a fake typhus epidemic in World War II^[8][9]
• Mickey Loomis, Willamette High School alumnus; general manager, New Orleans Saints, National Football League
• Stanley G. Love, astronaut^[10]
• Georgia Mason, botanist and herbarium curator^[11]
• Rich McKay, president and CEO of the Atlanta Falcons
• Wayne Morse, U.S. Senator
• Paul Pierson, political scientist
• Marty Ravellette, armless hero
• Paul Martin Simon, U.S. Senator from Illinois
• Wendell Wood, conservationist^[12]
• Don Z. Zimmerman, Brigadier General, first Dean of Faculty at the U.S. Air Force Academy
• John Zerzan, anarcho-primitivist writer, philosopher, activist