This is a listing of notable people who were born in, or have lived in, Flagstaff, Arizona. People whose only association with Flagstaff is attending, playing at, or coaching at Northern Arizona University should not be listed. For people who attended NAU see List of Northern Arizona University alumni.

Arts and entertainment

• Rutanya Alda – actress (Originally from Riga, Latvia, grew up in Flagstaff)
• Ted Danson – actor (Originally from San Diego, California)
• Andy Devine – actor
• R. Carlos Nakai – Native American flutist
• James Neilson – director (Originally from Shreveport, Louisiana
• Katie Pavlich – journalist, author (Originally from Phoenix, Arizona)

Literature

• Harvey Butchart – author, mathematician
• Ann Cummins – author (Originally from Durango, Colorado)
• Diana Gabaldon – author^[1] (Originally from Scottsdale, Arizona)

Military

• Amir Mirza Hekmati – U.S. Marine held prisoner by Iran for spying while visiting his grandmother

Politics

• Henry F. Ashurst – one of Arizona's first two Senators (Originally from Winnemucca, Nevada)
• Bruce Babbitt – former governor, and former United States Secretary of the Interior^[2]
• Paul Gosar – House of Representatives (Originally from Rock Springs, Wyoming)
• Ann Kirkpatrick – House of Representatives (Originally from McNary, Arizona)
• Ned Norris Jr. – chairman of the Tohono O'odham Nation
• Adam Perez Diaz – the first Hispanic to serve as Vice-Mayor of Phoenix.
• Rick Renzi – House of Representatives (Originally from Fort Monmouth, New Jersey)
• John Verkamp – state representative (Originally from Grand Canyon Village, Arizona)

Science and medicine

• William J. Breed – geologist, paleontologist, naturalist, author (Originally from Massillon, Ohio)
• Edwin H. Colbert – paleontologist, author (Originally from Clarinda, Iowa)
• Grady Gammage – educator, president ASU and NAU (Originally from Prescott, Arkansas)
• E. S. Gosney – eugenicist (Originally from Kenton County, Kentucky)
• Percival Lowell – astronomer, businessman, author (Originally from Boston, Massachusetts)
• Harold Masursky – geologist, astronomer (Originally from Fort Wayne, Indiana)
• Dale Shewalter – educator, outdoorsman (Originally from Geneva, Illinois)
• Eugene Merle Shoemaker – geologist, one of the founders of the field of planetary science, co-discoverer of Comet Shoemaker–Levy 9 (Originally from Los Angeles, California)
• Earl C. Slipher – astronomer, Mayor of Flagstaff (Originally from Mulberry, Indiana)
• Vesto Slipher – astronomer (Originally from Mulberry, Indiana)
• Clyde Tombaugh – astronomer, discoverer of Pluto (Originally from Streator, Illinois)

Sports

• Lyza Bosselmann – professional football player
• Donnie Hickman – professional football player
• Kyle Lobstein – professional baseball pitcher
• Eric McCain – professional football player^[3]
• Max Settlage – pair figure skater (Originally from Thừa Thiên–Huế Province, Vietnam)