Numerous notable people have lived in or come from Guam.

Entertainment

• Jason Barnes
• Nathaniel Berg
• Q. Allan Brocka
• Ann Curry
• Dan Ho
• Pia Mia
• Donovan Patton
• DPR Live

Games and athletics

• Morgan Hikaru Aiken
• Frank Camacho
• Jeff Cobb
• Jason Cunliffe
• Joe Duarte
• Christopher Duenas
• Victoria Muniz
• Daniel O'Keeffe
• Sean Reid-Foley
• Ray Robson
• Benjamin Schulte
• Pilar Shimizu
• William Stinnett
• Jon Tuck
• Derek Mandell

Business

• Eloise Baza

Diplomacy

• Yuri Kim

Lawyers

• Leevin Camacho
• Benjamin Cruz
• Alicia Limtiaco
• Douglas Moylan
• Don Parkinson

Military

• Peter Gumataotao
• Curtis W. Howard
• Susan Pangelinan

Politics

Activists

• Siobhon McManus

Delegates

• Vicente T. Blaz
• Madeleine Bordallo
• Michael San Nicolas
• Robert A. Underwood
• Antonio Borja Won Pat

Governors

Appointed

• Marcellus Boss (acting)
• William Corbett (acting)
• Bill Daniel
• Ford Quint Elvidge
• Joseph Flores
• Manuel Flores Leon Guerrero
• Richard Barrett Lowe
• Carlton Skinner

Elected

• Joseph Franklin Ada
• Ricardo Bordallo
• Eddie Calvo
• Paul McDonald Calvo
• Carlos Camacho
• Lou Leon Guerrero (current)
• Felix Perez Camacho
• Carl T.C. Gutierrez

Senators

Current

• Regine Biscoe Lee
• Telena Cruz Nelson
• Kelly Marsh Taitano
• Tina Rose Muña Barnes
• Amanda Shelton
• Pedo Terlaje
• Therese M. Terlaje

Former

• Tom Ada
• Frank Aguon
• John P. Aguon
• Elizabeth P. Arriola
• Madeleine Bordallo
• Ricardo Bordallo
• Benjamin Cruz
• Herminia D. Dierking
• Ping Duenas
• James Espaldon
• Alfred Flores
• Judith Guthertz
• Carl Gutierrez
• Marcia K. Hartsock
• Lou Leon Guerrero
• Manuel Flores Leon Guerrero
• Manuel U. Lujan
• Tommy Morrison
• Ted S. Nelson
• Tony Palomo
• Ben Pangelinan
• Don Parkinson
• John F. Quan
• Franklin Quitugua
• Ignacio P. Quitugua
• Edward Diego Reyes
• Joe T. San Agustin
• Michael San Nicolas
• Angel Santos
• Francis E. Santos
• Francisco R. Santos
• Dave Shimizu
• Nerissa Bretania Underwood
• Antonio Borja Won Pat
• Judith Won Pat

Mayors

• John A. Cruz
• Felix Ungacta

International organizations

• Bob Beck
• Lourdes Pangelinan

Other

• Walt Nauta, valet to Donald Trump