Richard Holcomb (born 1976) — human rights advocate, street outreach worker, HIV prevention counselor, and co-founder of Project Weber/Renew
Cornelia Bryce Pinchot (1881–1960) – Newport native who became a conservationist, Progressive politician, women's rights activist, and First Lady of Pennsylvania
Mary Reilly (born 1930) — teacher, leader, advocate for girls and women living in poverty
John Brown (1736–1803) – merchant and slave-trader, original owner of the John Brown House, co-founder of the College in the English Colony of Rhode Island and Providence Plantations (Brown University)
Moses Brown (1738–1836) – co-founder of the College in the English Colony of Rhode Island and Providence Plantations (Brown University)
Nicholas Brown Jr. (1769–1841) – businessman and philanthropist for whom Brown University is named
William McCormick (born 1939) – diplomat, United States Ambassador to New Zealand
J. Howard McGrath (1903–1966) – Governor of Rhode Island, Solicitor General, Senator, chairman of the Democratic National Committee, and Attorney General of the United States
Florence K. Murray (1916–2004) – officer in Women's Army Corps, first female state senator in Rhode Island, first female judge in Rhode Island, and first female member of the Rhode Island Supreme Court
Dee Dee Myers (born 1961) – White House Press Secretary
Annette Nazareth (born 1956) – commissioner of the Securities and Exchange Commission
Samuel Ward (1725–1776) – RI Supreme Court justice, Governor of the Colony of Rhode Island and Providence Plantations, and a delegate to the Continental Congress
James Manning (1738–1791) – American Baptist minister, co-founder and first president of the College in the English Colony of Rhode Island and Providence Plantations (Brown University)
Ezra Stiles (1727–1795) – Congregationalist minister and co-founder of the College in the English Colony of Rhode Island and Providence Plantations]]
Roger Williams (1603–1684) – founder of the Colony of Rhode Island and Providence Plantations, influential author, considered the first proponent of separation of church and state