Below is a list of notable people from Skopje, North Macedonia or its surroundings.

Artists

• Bojana Barltrop, artist and photographer

Fashion designers

• Nikola Eftimov

Painters

• Sabri Berkel
• Abdurrahim Buza
• Maja Dzartovska
• Petar Gligorovski
• Mice Jankulovski
• Petar Mazev

Business, industry, academics

• Dragoslav Avramović, economist, governor of the National Bank of Yugoslavia
• Dimitrije Bužarovski, scientist
• Marko Čalasan, youngest information technology engineer in the world, has worked for Microsoft since age 9
• Ljubomir Maksimović, historian
• Veni Markovski, Internet pioneer
• Zoran T. Popovski, scientist and professor
• Şarık Tara, founder of ENKA
• Mike S. Zafirovski, businessman involved in the success of several American companies

Musicians, bands, composers

• Lorenc Antoni, composer
• Arhangel, band
• Darko Dimitrov, songwriter, composer, and music producer
• Adrian Gaxha, singer
• Vaska Ilieva, folk singer
• Andrijana Janevska, singer
• Vlado Janevski, singer
• Jovan Jovanov, singer and composer
• Andrea Koevska, singer who will represent North Macedonia in the Eurovision Song Contest 2022
• Aleksandar Makedonski
• Lindon Berisha, singer and songwriter
• Mizar, band
• Blagoj Nacoski, tenor opera singer
• Goce Nikolovski, singer
• Barbara Popović, singer
• Kanita, singer
• Esma Redžepova, vocalist
• Elena Risteska, singer and songwriter
• Altuna Sejdiu, singer
• Muharem Serbezovski, singer
• Branimir Štulić, singer and composer
• Tamara Todevska, singer who represented North Macedonia in the Eurovision Song Contest 2019
• Tijana Todevska-Dapčević, singer
• Simon Trpceski, classical pianist
• Martin Vučić, singer
• Toni Zen, rapper

Movie, television figures, models and journalists

• Filiz Ahmet, actress
• Milka Babović, figure skating TV presenter
• Petar Gligorovski, animated movie director
• Katarina Ivanovska, model
• Ivo Jankoski, producer, fine arts manager, publisher and promoter
• Milčo Mančevski, film director
• Labina Mitevska, actress
• Naum Panovski, theatre director and writer
• Dragan Pavloviḱ Latas, journalist
• Stole Popov, film director
• Ljubiša Samardžić, actor
• Alaettin Tahir, journalist
• Avni Qahili, journalist

Politicians and historical figures

• Strašo Angelovski
• Vlado Bučkovski, former Prime Minister of the Republic of Macedonia
• Constantine Tikh of Bulgaria, Tsar of Bulgaria
• Stevo Crvenkovski, former foreign minister of Macedonia
• Boris Drangov, Bulgarian colonel
• Lazar Elenovski, Macedonian Minister of Defence
• Ljubomir Frčkoski, former presidential candidate
• Atanasije II Gavrilović, Patriarch of the Serbian Orthodox Church
• Nevena Georgieva, youngest fighter and first woman among the Macedonian Yugoslav partisan units
• Nikola Gruevski, former Prime Minister of Macedonia
• Ratko Janev, atomic physicist
• Zoran Jolevski, Macedonian ambassador to the United States
• Justin I, Eastern Roman Emperor
• Justinian I, Eastern Roman Emperor
• Kalinik I, Patriarch of the Serbian Orthodox Church
• Srgjan Kerim, former president of the United Nations General Assembly
• Emil Kirjas, politician
• Blerim Reka, politician
• Zana Ramadani, German politician
• Trifun Kostovski, former mayor of Skopje
• Maksim I, Serbian Patriarch
• Venko Markovski, writer, poet and political figure
• Ljubomir Mihajlovski, former Minister of Internal Affairs
• Ilinka Mitreva, former foreign minister
• Jordan Nikolov Orce, communist and partisan
• Bujar Osmani, current Minister of Foreign Affairs
• Radmila Šekerinska, current Minister of Defense
• Ali Shefqet Shkupi, Lieutenant Colonel
• Theodahad, King of the Ostrogoths
• Vasil Tupurkovski

Sports figures

• Vlatko Andonovski, former head coach of the United States women's national soccer team
• Lirim Zendeli, German racer
• Pero Antić, basketball player
• Boban Babunski, football coach
• Agim Sopi, football coach
• Aleksandar Bajevski, footballer
• Muharem Bajrami, footballer
• Enis Bardhi, footballer
• Mirjana Boševska, freestyle and medley swimmer
• Aleksandar Colovic, chess player
• Besir Demiri, footballer
• Ertan Demiri, footballer
• Filip Despotovski, footballer
• Fisnik Zuka – footballer
• Kiril Dojčinovski, former Yugoslav footballer
• Mario Đurovski, football striker for FK Vojvodina
• Antonio Filevski, retired footballer
• Jane Gavalovski, footballer
• Enver Idrizi, karateka
• Saša Ilić, goalkeeper
• Filip Ivanovski, footballer
• Čedomir Janevski, head coach of the Macedonia national football team
• Zoran Jovanovski, footballer
• Suat Zendeli – footballer
• Stefan Kozlov, tennis player
• Luka Nakov, footballer
• Zlatko Nastevski, retired footballer
• Nderim Nexhipi, footballer
• Ardian Nuhiu, footballer
• Žarko Odžakov, retired footballer
• Darko Pančev, European Cup-winning footballer
• Drita Islami – Macedonian hurdler
• Afrodita Salihi – footballer
• Aleksandar Popovski, footballer
• Lazar Popovski, kayaker
• Zekirija Ramadani, footballer
• Ivana Rožman, track and field athlete
• Berat Sadik, Finnish striker
• Predrag Samardžiski, basketball player
• Dušan Savić, footballer
• Shaban Sejdiu, wrestler
• Kiril Simonovski, footballer
• Jasir Asani – footballer
• Metodije Spasovski, former footballer
• Goran Stankovski, footballer
• Mevlan Adili – footballer
• Muhamed Demiri, footballer
• Darko Tasevski, footballer
• Goce Toleski, footballer
• Sedat Berisha – footballer
• Shaban Tërstena, wrestler
• Aleksandar Vasoski, defender for Eintracht Frankfurt
• Blagoja Vidinić, former football coach and former football player
• Muzafer Ejupi, footballer
• Zoran Zlatkovski, footballer

Writers, novelists, and poets

• Yahya Kemal Beyatlı, poet
• Rumena Bužarovska, writer
• Elena Filipovska, philologist, teacher, writer
• Slavko Janevski, poet, prose writer
• Venko Markovski, writer, poet and political figure
• Olivera Nikolova, novelist
• Naum Panovski, writer
• Aleksandar Prokopiev, novelist and essayist
• Goce Smilevski, writer
• Jovica Tasevski-Eternijan, poet, essayist, and literary critic
• Gane Todorovoski, poet, author, translator, essayist

Others

• Ana Colovic Lesoska, environmental activist
• Mother Teresa, Roman Catholic nun (now Saint Teresa of Calcutta)
• Nathan of Gaza, Jewish mystic