This is a list of notable people from St. Louis or St. Louis County in the U.S. state of Missouri. The dates in parentheses represent lifespan, not necessarily dates of actual residence in the city.

A

• Janet Adair (c. 1892–1938), vaudeville and musical comedy performer
• Brooke Adams (born 1984), professional wrestler, best known as Brooke Tessmacher
• Akon (born 1973), real name Aliaune Damala Badara Akon Thiam, musician
• Matt Alber (born 1975), singer-songwriter, musician^[1]
• Wilhelm Albers (1840–1904), Wisconsin State Assemblyman
• Devon Alexander (born 1987), professional boxer, IBF welterweight world champion
• Raleigh DeGeer Amyx (1938–2019), collector of Olympic and Presidential memorabilia^[2]
• Maya Angelou (1928–2014), poet, playwright, memoirist (I Know Why the Caged Bird Sings)
• Eberhard Anheuser (1805–1880), businessman, owner of company that would become Anheuser-Busch
• Donald K. Anton (born 1960), Chair of International Law at Griffith University
• Henry Armstrong (1912–1988), professional boxer, welterweight champion 1938–1940
• Dick Ault (1925–2007), track and field athlete

B

• Josephine Baker (1906–1975), dancer, singer, actress, Légion d'Honneur appointee, civil rights activist
• Scott Bakula (born 1954), actor (Quantum Leap, Star Trek: Enterprise)
• James F. Ballard (1851–1931), pharmaceutical entrepreneur, and art collector
• Thomas P. Barnett (1870–1929), architect and impressionist painter
• Tom Barlow (1995), who was a professional player for MLS NYRB.
• Fontella Bass (1940–2012), soul and R&B singer ("Rescue Me")
• Bradley Beal (born 1993), guard for the Phoenix Suns of the National Basketball Association
• Cool Papa Bell (1903–1991), Negro league baseball player, Hall of Fame member
• Katherine Bernhardt (born 1975), Contemporary artist, painter
• Robert Benecke (1835–1903), early photographer
• Graham Bensinger (born 1986), sports journalist for ESPN Radio
• Sally Benson (1897–1972), author whose short stories became the book, then movie, Meet Me in St. Louis
• Yogi Berra (1925–2015), Major League Baseball player (New York Yankees 1946–1963), manager, coach, Hall of Famer
• Chuck Berry (1926–2017), Rock and Roll Hall of Fame musician and composer ("Johnny B. Goode")
• Fred Berry (1951–2003), actor (What's Happening!!)
• Joe Besser (1907–1988), actor, comedian, member of The Three Stooges
• Alan Best (1906–1953), Illinois state representative
• Jud Birza (born 1989), model, winner of Survivor: Nicaragua
• Linda Blair (born 1959), actress (The Exorcist)
• Fred Blassie (1918–2003), professional wrestler
• Sean Blakemore (born 1967), actor, Shawn Butler on ABC's General Hospital
• Henry Blossom (1866–1919), novelist and playwright, opera librettist, and lyricist for Broadway musicals.
• Susan Blow (1843–1916), educator, opened first successful public kindergarten in the U.S.
• Jason Bolden (born 1982), celebrity fashion stylist and television personality
• Michele Boldrin (born 1956), Italian-American politician, economist, academic
• Kit Bond (born 1939), U.S. Senator from Missouri
• Daniel Boone (1734–1820), explorer, hunter, soldier, businessman, politician
• Evan Bourne (born 1983), WWE professional wrestler
• Dylan Brady (born 1993), musician
• Martin Stanislaus Brennan (1845–1927), Catholic priest and scientist
• Christine Brewer (born 1955), Grammy Award winner, soprano
• Lottie Briscoe (1883–1950), stage and silent film actress
• Lou Brock (1939–2020), Major League Baseball player (St. Louis Cardinals 1964–1979), Hall of Famer
• Shirley Brown (born 1947), soul/R&B singer ("Woman to Woman")
• Sterling K. Brown (born 1976), actor
• Steve Brown (born 1962), darts player
• Butch Buchholz (born 1940), Hall of Fame tennis player
• Jack Buck (1924–2002), Hall of Fame sportscaster, St. Louis Cardinals' announcer 1969–2002
• Joe Buck (born 1969), sportscaster, football and baseball announcer for Fox, son of Jack Buck
• Mark Buehrle (born 1979), Major League Baseball pitcher (Chicago White Sox, Toronto Blue Jays)
• Grace Bumbry (born 1937), opera singer
• Nelle G. Burger (1869–1957), president, Missouri State Woman's Christian Temperance Union
• T-Bone Burnett (born 1948), rock and country performer, composer, and producer
• William S. Burroughs (1914–1997), novelist, social critic, spoken-word performer; grandson of inventor William Seward Burroughs I
• William Seward Burroughs I (1855–1898), inventor of the adding machine, founder of Burroughs Corporation; grandfather of novelist William S. Burroughs
• Adolphus Busch (1839–1913), co-founder of Anheuser-Busch with father-in-law Eberhard Anheuser
• Adolphus Busch III (1891–1946), president and CEO of Anheuser-Busch; son of August Anheuser Busch, Sr.
• August Anheuser Busch, Sr. (1865–1934), president and CEO of Anheuser-Busch; son of Adolphus Busch
• Gussie Busch (August Anheuser Busch, Jr.) (1899–1989), president and CEO of Anheuser-Busch, civic leader, philanthropist
• August Busch III (born 1937), president and CEO of Anheuser-Busch, civic leader
• August Busch IV (born 1964), president and CEO of Anheuser-Busch, civic leader
• Cori Bush (born 1976), U.S. Representative from Missouri
• Champ Butler (1926–1992), singer^[3]
• Norbert Leo Butz (born 1967), Tony Award-winning actor
• Jim Byrnes (born 1948), actor and musician (Wiseguy, Highlander: The Series)
• Joaquin Buckley (born 1994) Mixed martial arts fighter

C

• Caroline Thomas Rumbold, (1877–1949), botanist
• Thomas Cahill (1864–1951), athlete, coach, businessman; a founding father of American soccer
• Haydee Campbell (d. 1921), kindergarten pioneer in St. Louis
• Kate Capshaw (born 1953), actress (Indiana Jones and the Temple of Doom), wife of Steven Spielberg
• Chip Caray (born 1965), sportscaster for Chicago Cubs, Atlanta Braves and Fox
• Harry Caray (1914–1998), sportscaster, lead announcer for the St. Louis Cardinals (1945–1969) and Chicago Cubs (1981–1997)
• Skip Caray (1939–2008), sportscaster, announcer for the Atlanta Braves (1976–2008)
• Nell Carter (1948–2003), Tony Award-winning singer and actress (Ain't Misbehavin')
• Lucille Cavanagh (1895–1983), vaudeville dancer, later columnist for the Los Angeles Times
• Louis Cella (1866–1918), capitalist, real estate mogul, turfman, and political financier
• Lori Chalupny (born 1984), U.S. women's national soccer team member
• Cedric the Entertainer (born 1964), actor and comedian
• Jean Baptiste Charbonneau (1805–1866), explorer, guide, fur trader, military scout, mayor, and gold prospector, born to Sacagawea during the Lewis and Clark Expedition and raised in St. Louis by William Clark
• John Cheatham (1855–1918), American firefighter
• C. J. Cherryh (born 1942), science-fiction novelist
• Chingy (born 1980), real name Howard Bailey, Jr., hip-hop recording artist and actor
• Kate Chopin (1851–1904), novelist (The Awakening)
• Auguste Chouteau (1740–1829), co-founder of St. Louis, urban planner, businessman, civic leader
• David Clarenbach (born 1953), member of Wisconsin State Assembly
• William Clark (1770–1838), explorer, government administrator
• Sarah Clarke (born 1972), actress (24)
• Mac Cody (born 1972), football player in NFL, CFL, AFL^[4]
• Cynthia Coffman (born 1962), American murderer
• Andy Cohen (born 1968), television executive and personality at Bravo network, one of the first openly gay talk-show hosts
• Barry Commoner (1917–2012), biologist, college professor, eco-socialist, and presidential candidate
• Arthur Compton (1892–1962), physicist, Nobel Prize in Physics 1927
• Jimmy Connors (born 1952), professional tennis player, 5-time U.S. Open winner in men's singles
• Bert Convy (1933–1991), actor and game-show host
• Sam Coonrod (born 1992), major league pitcher
• Carl Ferdinand Cori (1896–1984); Gerty Cori (1896–1957), biochemists, joint Nobel Prize in Physiology or Medicine 1947
• Zlatko Ćosić (born 1972), artist and filmmaker
• Bob Costas (born 1952), sportscaster, talk-show host
• Bryan Cox (born 1968), NFL linebacker 1991–2002
• Jim Cox (1920–2014), professional football player
• Lavell Crawford (born 1968), stand-up comedian, actor
• Anton Crihan (1893–1993), Romanian politician, professor at University of Paris (Sorbonne)
• James Cuno (born 1951), art historian and museum director

D

• Paul Dana (1975–2006), IndyCar Series driver
• John Danforth (born 1936), statesman, diplomat, attorney, civic leader, U.S. Senator 1977–1995
• William H. Danforth (1870–1956), founder of Ralston Purina Company; grandfather of John Danforth and William H. "Bill" Danforth
• William H. "Bill" Danforth (1926–2020), physician, professor of medicine, and chancellor of Washington University in St. Louis 1971–1995
• Billy Davis Jr. (born 1938), R&B and soul singer, member of The 5th Dimension
• Brad Davis (born 1981), professional soccer player
• Dwight F. Davis (1879–1945), athlete, government administrator
• Miles Davis (1926–1991), jazz composer and musician, winner of Grammy Lifetime Achievement Award
• April Daye (born 1937), burlesque dancer, fine arts painter, recording artist and jazz singer
• Dizzy Dean (1910–1974), baseball pitcher, broadcaster
• Dan Dierdorf (born 1949), football player, broadcaster
• Phyllis Diller (1917–2012), comedian
• John Doerr (born 1951), venture capitalist
• Domino (born 1972), real name Shawn Antoine Ivy, rapper, born in St. Louis
• Colin Donnell (born 1982), actor, Arrow
• Thom Donovan (born 1974), musician (Lapush)
• Don Doran (born 1954), retired professional soccer player
• Jack Dorsey (born 1976), software architect and businessperson, creator of Twitter and Square
• Bob Dotson (born 1946), broadcast journalist, NBC correspondent
• Tyler Downs (born 2003), U.S. Olympic diver
• Dora Doxey (1879–1921), accused of murder in 1909; found not guilty
• Katherine Dunham (1909–2006), dancer
• Tim Dunigan (born 1955), actor
• Mary Alice Dwyer-Dobbin (fl. 1972 – c. ??), television producer

E

• James Eads (1820–1887), engineer
• Thomas Eagleton (1929–2007), statesman, attorney, civic leader
• Charles Eames (1907–1978), designer, filmmaker
• Oliver Eckhardt (1873-1952), actor
• William C. Edenborn (1848–1926), industrialist and inventor
• Jonathan Edwards (born 1944), singer member of The Spinners (American group)
• T. S. Eliot (1888–1965), poet (Nobel Prize, Presidential Medal of Freedom), critic
• William Greenleaf Eliot (1811–1887), educator, medical reformer, civil rights activist; grandfather of T. S. Eliot
• Ezekiel Elliott (born 1995), Professional Football player Dallas Cowboys
• Stanley Elkin (1930–1995), author
• Mary Engelbreit (born 1952), artist
• Glennon Engleman (1927–1999), hitman
• Walker Evans (1903–1975), photographer
• Steve Ewing (fl. 1987 – c. ??), singer/actor, The Urge

F

• Max Factor (1904–1996), cosmetics maker
• Lee Falk (1911–1999), comic strip creator
• Eugene Field (1850–1895), author
• Shandi Finnessey (born 1978), Miss USA 2004
• Jenna Fischer (born 1974), actress
• Jamar Fletcher (born 1979), professional football player
• Jason Fletcher (born 1975), sports agent
• Ellen Foley (born 1951), singer, actress
• Mike Ford (born 1995), professional football player
• Richard Fortus (born 1966), musician, Guns N' Roses
• Redd Foxx (1922–1991), comedian, actor
• Malcolm Frager (1935–1991), concert pianist
• James Franciscus (1934–1991), actor (Mr. Novak, Longstreet)
• Clint Frank (1915–1992), college football halfback, Heisman Trophy winner in 1937
• Mary Frann (1943–1998), actress (Newhart)
• Jonathan Franzen (born 1959), author
• Trent Frederic (born 1998), ice hockey player
• David Freese (born 1983), baseball player
• Jaime French (born 1989), comedian, YouTuber, make-up artist
• Tom Friedman (born 1965), artist

G

• Bob Gale (born 1951), screenwriter, film producer
• Alberta Gallatin (1861–1948), stage and screen actress, raised in St. Louis
• Charles Henry Galloway (1871–1931), St. Louis organist, choral conductor, educator, and composer
• Pud Galvin (1856–1902), Major League Baseball player^[5]
• Joe Garagiola (1926–2016), baseball player, sportscaster, television personality, author
• Jan Garavaglia (born 1956), Chief Medical Examiner of the District 9 Morgue in Orlando, Florida; television personality
• Dave Garroway (1913–1982), television personality, first host of NBC's Today Show
• William H. Gass (1924–2017), author, critic
• Martha Gellhorn (1908–1998), author and journalist; third wife of Ernest Hemingway
• Richard Gephardt (born 1941), politician
• Steve Gerber (1947–2008), comic-book writer, co-creator of Howard the Duck
• Frances Ginsberg (1955–2010), opera singer
• David Giuntoli (born 1981), actor
• Nikki Glaser (born 1984), comedian
• Martin Goldsmith (born 1952), music writer and radio personality
• John Goodman (born 1952), actor
• Harry Goz (1932–2003), actor, Sealab 2021
• Betty Grable (1916–1973), actress
• Grant Green (1935–1979), jazz guitarist
• Trent Green (born 1970), football player
• Frank S. Greene (1938–2009), Semiconductor researcher and technologist
• Dick Gregory (1932–2017), author, comedian, civil rights
• Eric Greitens (born 1974), 56th Governor of Missouri
• Kim Gruenenfelder (fl. 1992 – c. ??), author
• Charles Guenther (1920–2008), poet, translator, newspaper critic
• Robert Guillaume (1927–2017), Grammy and Emmy Award-winning actor
• James Gunn (born 1966), screenwriter, director
• Sean Gunn (born 1974), actor
• Moses Gunn (1929–1993), actor
• Virginia Gibson (1925–2013), dancer, singer, actress

H

• Emily Hahn (1905–1997), journalist, author
• Laurell K. Hamilton (born 1963), author
• Jon Hamm (born 1971), Golden Globe Award and Primetime Emmy Award award-winning actor, Mad Men
• Henry Hampton (1940–1998), film producer, Eyes on the Prize: America's Civil Rights Years (1954–1965) and Eyes on the Prize II: America at the Racial Crossroads (1965–1980s)
• Sally Hampton (born 1958), writer, producer
• Harry Hanebrink (1927–1996) Major League Baseball player. Milwaukee Braves (1953, 1957–1958)
• Chuck T. Harmon (born 1979), aka Chuck Harmony, music producer for Mary J. Blige, Celine Dion, Fantasia, Rihanna
• Doris Hart (1925–2015), Hall of Fame tennis player, two-time U.S. Open champion
• John Hartford (1937–2001), musician, Grammy Award winner
• Culver Hastedt (1883–1966), runner, gold medal winner at 1904 Summer Olympics
• Donny Hathaway (1945–1979), Grammy-winning singer, songwriter, producer, composer
• Pat Healy (born 1983), mixed martial arts fighter
• Bob Heil (born 1940), sound and radio engineer
• Julius Hemphill (1938–1995), jazz saxophonist, composer
• George E. Hibbard (1924–1991), art collector, advocate for Tibetan Independence
• George Hickenlooper (1963–2010), filmmaker
• Paul John Hilbert (1949–2001), member of the Texas House of Representatives^[6]
• Malcolm Hill (born 1995), American player in the Israel Basketball Premier League
• Al Hirschfeld (1903–2003), artist and cartoonist
• Bobby Hofman (1925–1994), Major League Baseball player
• Solly Hofman (1882–1956), Major League Baseball player
• Erin Marie Hogan (born 1985), actress and activist
• Robert A. Holekamp (1848–1922), businessman and apiarist
• Jessie Housley Holliman (1905–1984), educator, public muralist, artist
• William H. Holloman III (1924–2010), U.S. Army Air Force officer and combat fighter pilot with the Tuskegee Airmen; U.S. Air Force’s first African American helicopter pilot.^[7][8][9]
• August Holtz (1871–1938), United States Navy sailor, Medal of honor recipient
• Ken Holtzman (born 1945), baseball pitcher
• A. E. Hotchner (1917–2020), author, editor, philanthropist
• Elston Howard (1929–1980), baseball player, first black player for New York Yankees
• Ryan Howard (born 1979), baseball player, 2005 NL Rookie of the Year, 2006 National League MVP and All-Star first baseman, Philadelphia Phillies
• Huey (1987–2020), real name Lawrence Franks, Jr., rapper
• Larry Hughes (born 1979), basketball player, Chicago Bulls

I–J

• Vedad Ibišević (born 1984), Bosnian soccer player
• Eliza Buckley Ingalls (1848–1918), American temperance activist
• William Inge (1913–1973), Pulitzer Prize-winning playwright
• Palestina "Tina" Isa (1972–1989), honor killing victim^[10]
• Ernie Isley (born 1952), songwriter, guitarist of soul and R&B group The Isley Brothers
• Ronald Isley (born 1941), lead singer of The Isley Brothers; co-owns St. Louis-based Notifi Records
• Halsey Ives (1847–1911), museum and school founder, director of two world-fair art exhibitions (Louisiana Purchase Exposition and World's Columbian Exposition)
• Oliver Lee Jackson (born 1935), painter, sculptor, draftsman, and printmaker
• Sean James (born 1978), athlete
• Cam Janssen (born 1984), ice hockey player
• Ella Jenkins (born 1924), musician
• Jibbs (born 1990), real name Jovan Campbell, rapper
• J-Kwon (born 1986), real name Jerrell Jones, rapper
• Jeremiah Johnson (born 1972), blues musician^[11]
• Johnnie Johnson (1924–2005), musician
• Scott Joplin (1867/1868–1917), songwriter (Pulitzer Prize), musician, "King of Ragtime"
• Jackie Joyner-Kersee (born 1962), Olympic gold-medalist track & field athlete; educator; sister of Olympic athlete Al Joyner; sister-in-law of Florence "Flo Jo" Griffith-Joyner
• Judith McNaught (born 1944), novelist

K

• Kane (born 1967), real name Glenn Jacobs, professional wrestler
• Stan Kann (1924–2008), musician, entertainer
• Terry Karl (born 1947), professor of Latin American Studies at Stanford University
• Bruce Karsh (born 1955), lawyer and investor
• Ben Kasica (born 1984), musician
• Karen Katen (born 1948), pharmaceutical executive
• Andreas Katsulas (1946–2006), actor (Babylon 5)
• David Kaufman (born 1969), character actor and voice actor (Danny Phantom)
• Jim Kekeris (1923–1997), NFL player
• Ellie Kemper (born 1980), actress
• Dorothea Kent (1916–1990), film actress
• Dickie Kerr (1893–1963), baseball pitcher
• Al Kerth (1952–2002), public relations professional
• Imrat Khan (1935–2018), Indian classical musician
• Albert King (1923–1992), musician
• Silver King (1868–1938), Major League Baseball player^[5]
• Audrey Kissel (1926–2017), All-American Girls Professional Baseball League player
• Kevin Kline (born 1947), Academy Award-winning actor
• Karlie Kloss (born 1992), model
• Marquise Knox (born 1991), blues rock musician^[12]
• Chris Koster (born 1964), Attorney General of Missouri
• Kyle O'Reilly (born 1987), real name Kyle Greenwood, professional wrestler
• Karyn Kusama (born 1968), filmmaker

L

• Pierre Laclede (1729–1778), urban planner; co-founder of St. Louis; government administrator; civic leader
• Pokey Lafarge (born 1983), musician and singer
• Pat LaFontaine (born 1965), NHL hockey player
• Elizabeth Laime (born 1979), podcaster, writer
• Oliver Lake (born 1942), jazz saxophonist, composer
• Christopher Largen (1969–2012), author, filmmaker, journalist, activist
• Jeannie Leavitt (born c. 1967), the United States Air Force's first female fighter pilot^[13]
• Bob Lee (1979–2023), software engineer and technology entrepreneur
• David Lee (born 1983), NBA basketball player
• Jim Lee, comic-book artist, writer, editor, publisher; President and Chief Creative Officer of DC Comics; founder of Wildstorm Productions and founding member of Image Comics^[14]
• Murphy Lee (1979), rapper
• Tod Leiweke (born 1960), sports executive
• Maggie LePique (born 1964), jazz radio host
• Laura Les (born 1994), musician
• Stacey Levine, fiction writer, journalist
• Jenifer Lewis (born 1957), actress
• Charles Lindbergh (1902–1974), adventurer, pilot, soldier, author
• Linda Lingle (born 1953), former Governor of Hawaii
• Theodore Link (1850–1923), architect
• Sonny Liston (1932–1970), heavyweight champion boxer
• John Long (born 1950), blues musician^[15]
• Taylor Louderman (born 1990), Broadway actress
• Carl Lutz (1895–1975), Swiss diplomat responsible for saving over 62,000 Jews during World War II

M

• Vicki Mabrey (born 1956), broadcast journalist
• Ed Macauley (1928–2011), Hall of Fame basketball player
• Jeremy Maclin (born 1988), football wide receiver (Baltimore Ravens)
• Justin Marks (born 1981), Former NASCAR driver, Co-Owner of Trackhouse Racing
• Patrick Maroon (born 1988), ice hockey player for the Tampa Bay Lightning
• James S. Marshall (1819–1892), Mayor of Green Bay, Wisconsin
• Cuonzo Martin (born 1971), basketball coach for the University of Missouri
• Peter Martin (born 1970), jazz pianist
• Marguerite Martyn (1878–1948), journalist and artist
• Mary Meachum (1801–1869), abolitionist
• John Berry Meachum (1789–1854), founder of the oldest black church in Missouri.

  

• Marsha Mason (born 1942), Golden Globe Award-winning and Oscar-nominated actress
• William H. Masters (1915–2001) and Virginia E. Johnson (1925–2013), members of a joint research team on human sexual response at Washington University in St. Louis
• Stan Masters (1922–2005), American realism artist
• Ron Mathis (born 1958), Major League baseball player
• Bill Mauldin (1921–2003), cartoonist, Pulitzer Prize winner
• Morton D. May (1914–1983), philanthropist, community leader, art collector, chairman of May Department Stores
• Scott Mayfield (born 1992), ice hockey player
• Virginia Mayo (1920–2005), born Virginia Clara Jones, actress
• Emmett McAuliffe (fl. 1976 – c. 2008), lawyer and talk show host
• Jimmy McCracklin (1921–2012), pianist, vocalist and songwriter
• Michael McDonald (born 1952), singer, Grammy Award winner, lead vocalist on The Doobie Brothers
• Margaret Bischell McFadden (1870–1932), philanthropist and social worker
• Robert McFerrin, Sr. (1921–2006), classical singer, father of Bobby McFerrin
• Scott A. McGregor (born 1956), technology executive and philanthropist
• Robert McHenry (born 1945), encyclopedist and author
• Jim McKelvey (born 1965), computer science engineer, co-founder of Square, a mobile payments company
• Mike McKenna (born 1983), NHL player for the Philadelphia Flyers
• Chuck McKinley (1941–1986), Hall of Fame tennis player, 1963 Wimbledon champion
• Ben McLemore (born 1993), basketball player
• George McManus (1884–1954), creator of comic strip Bringing Up Father
• Larissa Meek (born 1978), Miss Missouri Teen USA 1997, Miss Missouri 2001, creative director at BGT Partners
• David Merrick (1911–2000), theatrical producer (Tony Awards)
• Metro Boomin (born 1993), record producer, songwriter and DJ
• Joyce Meyer (born 1943), religious preacher and speaker
• Bob Miller (1939–1993), MLB pitcher, StL Cardinals, graduated from Beaumont High School
• Jay Miller (1943–1991), basketball player
• Marvin Miller (1913–1985), actor
• David Miller (born 1961), darts player
• George A. Mitchell (1824–1878), founder of Cadillac, Michigan
• Russ Mitchell (born 1960), journalist and television news anchor
• Marie Moentmann (1900–1974), child survivor of industrial accident, wearer of prosthetic device
• Taylor Momsen (born 1993), singer-songwriter, model, actress
• Archie Moore (1916–1998), boxer, world light-heavyweight champion
• Marianne Moore (1887–1972), poet (Pulitzer Prize), essayist, translator
• Agnes Moorehead (1900–1974), Emmy Award-winning and Oscar-nominated actress
• Thomas Morse (born 1968), composer
• Dorothy Morton (1869–1939), actress and soprano
• Bill Mueller (born 1971), baseball player and coach, St Louis Cardinals
• Nick Murphy (born 1979), NFL punter 2002–2005
• Stan Musial (1920–2013), Hall of Fame baseball player for the St. Louis Cardinals

N–O

• Nelly (born 1974), real name Cornell Haynes, Jr., rapper, singer and actor
• Oliver Nelson (1932-1975), jazz saxophonist, clarinetist, arranger, composer, and bandleader
• Howard Nemerov (1920–1991), poet (Pulitzer Prize, Poet Laureate of the United States), author, critic
• Eric Nenninger (born 1978), actor
• Eric P. Newman (1911–2017), numismatist
• Todd Newton (born 1970), game show host, radio personality
• Dustin Nguyen (born 1962), Vietnamese American actor
• Chase Niece (born 1998) soccer players who was free agents, last play for North Texas SC.
• Rich Niemann (born 1946), athlete
• Frank Nuderscher (1880–1959), American Impressionist painter
• Dan O'Bannon (1946–2009), screenwriter, director
• Gyo Obata (1923–2022), architect
• Anne-Marie O'Connor(fl. 2012 – c. ??), journalist, author
• St. Louis Jimmy Oden (1903–1977), real name James Burke Oden, blues musician
• Franklin W. Olin (1860–1951), industrialist, philanthropist
• Angel Olsen (born 1987), folk and indie rock musician
• Walter J. Ong (1912–2003), scholar
• Howard Orenstein (born 1955), Minnesota state legislator and lawyer
• *Annie L. Y. Orff (1861-1914), journalist; magazine editor and publisher
• Barry Orton (1958–2021), professional wrestler
• "Cowboy" Bob Orton (born 1950), former professional wrestler
• Randy Orton (born 1980), professional wrestler
• Josh Outman (born 1984), Major League Baseball player, Oakland Athletics

P–Q

• David Packouz (born 1982), international arms dealer and subject of 2016 film Arms and the Dudes
• Ken Page (born 1954), actor, voice actor, cabaret singer
• Lucia Pamela (1904–2002), musician, mother of Georgia Frontiere
• James Pankow (born 1947), trombone player, of Chicago
• John Pankow (born 1954), actor (Beverly Hills Cop, Mad About You)
• Leslie Parnas (1931–2022), classical cellist
• King Parsons (born 1949), professional wrestler
• Ann Peebles (born 1947), soul singer, songwriter
• D. H. Peligro (born 1959), real name born Darren Henley, drummer for Dead Kennedys and Red Hot Chili Peppers
• Frank P. Pellegrino (1901–1975), businessman, philanthropist, chief executive officer of International Hat Company
• Marlin Perkins (1905–1986), zoologist, Emmy Award-winning broadcaster
• Miguel Perez (born 2005), professional soccer player who is playing for St. Louis City SC in the MLS
• Evan Peters (born 1987), actor (American Horror Story)
• Mike Peters (born 1943), Pulitzer Prize-winning editorial cartoonist and comic strip artist, creator of Mother Goose and Grimm
• Homer G. Phillips (1880-1931), prominent lawyer and civil rights advocate, Homer G. Phillips Hospital named in his honor.^[16]
• Stone Phillips (born 1954), television journalist
• Julie Piekarski (born 1963), Mouseketeer, actress
• Bill Porter (1931–2010), audio engineer
• Otto Porter (born 1993), Small Forward of the Chicago Bulls
• Louise Post (born 1966), musician (Veruca Salt)
• Joseph W. Postlewaite (1827–1889), musician
• Emil Preetorius (1827–1905), journalist
• Vincent Price (1911–1993), actor (House of Wax, The Ten Commandments, The Fly, Edward Scissorhands)
• John G. Priest (1822–1900), real estate dealer, philanthropist, first St. Louis Veiled Prophet
• Victor Proetz (1897–1966), architect, designer, author of poetry and verse
• Joseph Pulitzer (1847–1911), publisher, philanthropist, creator of the Pulitzer Prize and many U.S. newspapers
• Kevin Puts (born 1972), composer, 2012 Pulitzer Prize in Music, 2023 Grammy Award for Best Contemporary Classical Composition

R

• Neil Rackers (born 1976), athlete, placekicker for Arizona Cardinals
• Harold Ramis (1944–2014), author, director, actor; graduated from Washington University (1966)
• Judy Rankin (born 1945), professional golfer and TV commentator, World Golf Hall of Famer
• David Rasche (born 1944), actor
• Peter H. Raven (born 1936), botanist, academic administrator, civic leader
• Hank Raymonds (1924–2010), coached Marquette University men's basketball 1977–83; athletic director 1977–87
• Tim Ream (born 1987), professional soccer player, defender for Fulham FC of Football League Championship and United States men's national soccer team
• Sexyy Red (born 1998), rapper
• Wallace Reid (1891–1923), actor, early cinema sex symbol
• Steven Reigns (born 1975), poet, activist, educator
• Hadley Richardson (1891–1979), first wife of Ernest Hemingway
• Branch Rickey (1881–1965), baseball executive
• Rob Riti (born 1976), football player
• Doris Roberts (1925–2016), actress (Everybody Loves Raymond)
• Leonard Roberts (born 1972), actor
• Lance Robertson (born 1965), musician and host of children's television show Yo Gabba Gabba! (as DJ Lance Rock)
• Harry Rogers (born 1950), professional basketball player
• Mike Rodgers (born 1985), track and field sprinter
• Irma S. Rombauer (1877–1962), author
• Jean Rouverol (1916–2017), author, actress and screenwriter; blacklisted in the 1950s
• Jack Rowe (1856–1911), major league baseball player^[5]
• Charles M. Russell (1864–1926), artist, storyteller

S

• John S. Samuel (1913–2002), U.S. Air Force Major General
• Claire Saffitz (born 1986), Chef and personality on Bon Appétit magazine's YouTube channel^[17]
• David Sanborn (born 1945), musician, Grammy Award winner
• Drew Sarich (born 1975), singer, songwriter, actor
• Becky Sauerbrunn (born 1985), soccer player
• Edward Saxon (born 1956), film producer (The Silence of the Lambs)
• Max Scherzer (born 1984), MLB pitcher
• Phyllis Schlafly (1924–2016), socially conservative Republican author, broadcaster, and political organizer
• Zander Schloss (born 1961), bassist for the Circle Jerks and The Weirdos; actor
• Red Schoendienst (1923–2018), Hall of Fame second baseman, coach, manager for St. Louis Cardinals
• Chris Schuler (born 1987), professional soccer player for Real Salt Lake
• Dred Scott (1799–1858) and Harriet Scott (1815–1860), civil rights activists
• Robert J. Sexton (fl. 1997 – c. ??), music video and virtual reality director, and former musician
• Art Shamsky (born 1941), Major League Baseball outfielder and Israel Baseball League manager
• Mike Shannon (1939-2023), affiliated with St. Louis Cardinals for over 50 years, as a player (1962–1970), in front office, and, since 1972, radio and TV announcer
• Scott Shannon (born 1947), a radio disk jockey hosting WCBS-FM in New York City.
• Augustus Shapleigh (1810–1902), president of Shapleigh Hardware Company and early pioneer of St. Louis
• Henry Shaw (1800–1889), botanist, philanthropist, businessman, author
• Rick Shaw (1938–2017), disc jockey, radio and television personality (WQAM, WAXY, WMXJ, WLBW), born in East St. Louis
• William Tecumseh Sherman (1820–1891), soldier; commander of United States Army
• Roberta Sherwood (1913–1999), singer and actress
• Sherman Silber (fl. 1966 – c. ??), physician and infertility specialist
• Frank Simek (born 1984), soccer player with Sheffield Wednesday, also USA International
• Kimora Lee Simmons (born 1975), model and mogul
• Leonard Slatkin (born 1944), conductor, Grammy Award winner
• Slayyyter (born 1996), pop musician
• Jane Smiley (born 1949), Pulitzer Prize-winning novelist
• Nikko Smith (born 1982), singer, American Idol contestant; son of Ozzie Smith
• Ozzie Smith (born 1954), Hall of Fame shortstop for St. Louis Cardinals
• Phyllis Smith (born 1952), actress on NBC's The Office and Disney's movie Inside Out
• Willie Mae Ford Smith (1904–1994), singer
• Cory Spinks (born 1978), world champion boxer
• Leon Spinks (1953–2021), world champion boxer
• Michael Spinks (born 1956), world champion boxer
• Max C. Starkloff (1858–1942), St. Louis Health Commissioner who introduced social distancing during the 1918 flu pandemic
• Paul Stastny (born 1985), hockey player for St. Louis Blues
• Yan Stastny (born 1982), hockey player for St. Louis Blues
• Harry Steinfeldt (1877–1914), Major League Baseball player^[5]
• Edward Steinhardt (born 1961), poet and author
• Chuck Stone (1924–2014), journalist, educator and civil rights activist
• Stevie Stone (born 1981), rapper, born in Columbia, raised in St. Louis, signed to Kansas City-based Strange Music
• Willie Sudhoff (1874–1917), Major League Baseball player^[5]
• Roosevelt Sykes (1906–1983), blues musician
• James W. Symington (born 1927), U.S. Representative, statesman, attorney
• SZA (born 1989), real name Solana Rowe, singer-songwriter, TDE (Top Dawg Entertainment) record label
• Smino (born 1991), real name Christopher Smith Jr, rapper, singer, songwriter, Zero Fatigue record label

T

• Jim Talent (born 1956), politician
• Jayson Tatum (born 1998), forward for the Boston Celtics of the National Basketball Association
• Sara Teasdale (1884–1933), poet (Pulitzer Prize)
• Clark Terry (1920–2015), jazz musician
• George Thampy (born 1987), 2000 Scripps National Spelling Bee champion
• Lou Thesz (1916–2002), professional wrestler
• David Thirdkill (born 1960), NBA basketball player; 1993 Israeli Basketball Premier League MVP
• Todd Thomas (born 1961), fashion designer
• Kay Thompson (1909–1998), singer, songwriter, author of Eloise books
• John L. Tiernon, (1841–1910), U.S. Army brigadier general^[18]
• Conrad Tillard (born 1964), politician, Baptist minister, radio host, author, and activist
• Cap Tilles (1865–1951), race track magnate, philanthropist, founder of Tilles Park
• Gina Tognoni (born 1973), actress
• Guy Torry (born 1969), actor and comedian
• Joe Torry (born 1965), actor and comedian
• Scott Touzinsky (born 1982), volleyball player and coach
• Henry Townsend (1909–2006), musician
• Toya (born 1983), real name LaToya Rodriguez, R&B singer
• Maury Travis (1965–2002), murderer and suspected serial killer
• Helen Traubel (1899–1972), classical and popular singer
• Julie Tristan (fl. 2012 – c. ??), American television personality
• Quincy Troupe (born 1939), poet, editor, journalist
• Ernest Trova (1927–2009), artist
• Ross H. Trower (1922–2014), Chief of Chaplains, U.S. Navy
• Harry S. Truman (1884–1972), 33rd U.S. President
• Truth Hurts (born 1971), real name Shari Watson, R&B singer
• Orrin Tucker (1911–2011), bandleader
• Debbye Turner (born 1965), Miss America 1990, TV journalist
• Ike Turner (1931–2007), singer, musician, agent and production administrator
• Jessie Franklin Turner (1881–1956), fashion designer
• Tina Turner (1939-2023), real name Anna Mae Bullock, Grammy Award-winning singer, actress, pop-culture icon
• Taylor Twellman (born 1980), professional soccer player
• Alex Tyus (born 1988), American-Israeli professional basketball player, also plays for Israeli national basketball team^[19][20]

U–V

• David King Udall (1851–1938), politician
• Mark Valenti (fl. 1985 – c. ??), screenwriter and novelist
• Courtney Van Buren (born 1980), National Football League player
• Mona Van Duyn (1921–2004), poet (Pulitzer Prize, Poet Laureate of the United States), editor
• George Van Haltren (1866–1945), Major League Baseball player^[5]
• Maria Rosa Villalpando (1738-1830), Hispanic woman, former captive of the Comanche and Pawnee
• Marilyn vos Savant (born 1946), columnist, known for having the world's highest IQ

W

• Jack Wagner (born 1959), actor
• Caroline Holme Walker (1863–1955), composer
• Rosa Kershaw Walker (1840s-1909), author, journalist, editor
• Kenny Wallace (born 1963), NASCAR driver
• Mike Wallace (born 1959), NASCAR driver
• Rusty Wallace (born 1956), NASCAR champion driver
• Steve Wallace (born 1987), NASCAR driver
• Trey Waltke (born 1955), tennis player, won ATP title in 1980
• Maxine Waters (born 1938), politician
• Leroy H. Watson (1893–1975), U.S. Army major general
• Earl Weaver (1930–2013), Hall of Fame baseball manager
• Dick Weber (1929–2005), professional bowler
• Harry Weber (born 1942), sculptor
• William H. Webster (born 1924), former director of the FBI and CIA, Chairman of the Homeland Security Advisory Council
• Dave Weckl (born 1960), musician, drummer
• Annie Wersching (1977-2023), actress, played Renee Walker on TV series 24
• Jo Jo White (1946–2018), basketball player
• Joseph T. White (1961–1985), United States Army soldier who defected to North Korea on August 28, 1982
• Verner Moore White (1863–1923), artist
• Marissa Whitley (born 1983), Miss Teen USA 2001
• Mary Wickes (1910–1995), actress
• Chris Wideman (born 1990), NHL player
• Bill Wilkerson (1945–2017), sports announcer and radio personality (KMOX)
• Violet Wilkey (1903–1976), actress
• Jameson Williams (born 2001), NFL player
• Melvin Williams (born 1979), NFL player
• Tennessee Williams (1911–1983), real name Thomas Lanier, Pulitzer Prize-winning playwright
• Mykelti Williamson (born 1957), actor, played Bubba Blue in 1994 film Forrest Gump
• Ike Willis (born c. 1957), musician
• Angela Winbush (born 1955), R&B/soul singer, songwriter
• Devon Windsor (born 1994), model
• Trey Wingo (born 1955), sports journalist (KSDK-TV, ESPN)
• Kellen Winslow (born 1957), NFL football player, Hall of Famer
• Shelley Winters (1920–2006), Academy Award-winning actress
• Edwin E. Woodman (1838–1912), Wisconsin State Senator
• Harriett Woods (1927–2007), politician; two-time Democratic nominee for the U.S. Senate from Missouri; former Lieutenant Governor
• Dan Wool (fl. 1986 – c. ??), musician, composer with group Pray for Rain

X–Z

• Clyde X (1931–2009), leader in the Nation of Islam