The following is a list of the presidents of the University of South Carolina from its founding as South Carolina College in 1801, to the present day.

Presidents of the University of South Carolina

No.	Image	Name	Tenure	Notes
1		Jonathan Maxcy	1804–1820
2		Thomas Cooper	1821–1834
–		Robert Henry	1834	President pro tempore
–		Henry Junius Nott	1834–1835	Chairman of the Faculty
3		Robert Woodward Barnwell	1835–1841
4		Robert Henry	1841–1845
5		William C. Preston	1845–1851
–		Francis Lieber	1851	President pro tempore
6		James H. Thornwell	1851–1855
7		Charles F. McCay	1855–1857
8		Augustus B. Longstreet	1857–1861
–		Maximilian LaBorde	1861–1865	Chairman of the Faculty
–		Robert Woodward Barnwell	1865–1873	Chairman of the Faculty
–		Benjamin B. Babbitt	1873–1875	Chairman of the Faculty
–		Anson W. Cummings	1875–1877	Chairman of the Faculty
9		William Porcher Miles	1880–1882
10		John McLaren McBryde	1883–1891
11		James Woodrow	1891–1897
12		Frank C. Woodward	1897–1902
13		Benjamin Sloan	1902–1908	Acting President from 1902 to 1903
–		Andrew C. Moore	1908–1909	Acting President
14		Samuel Chiles Mitchell	1909–1913
–		Andrew C. Moore	1913–1914	Acting President
15		William Spenser Currell	1914–1922
16		William Davis Melton	1922–1926
–		Leonard T. Baker	1926	Acting President
17		Davison McDowell Douglas	1927–1931
18		Leonard T. Baker	1931–1936
19		James Rion McKissick	1936–1944
–		Leonard T. Baker	1944–1945	Acting President
20		Norman Murray Smith	1945–1952
–		Francis Wright Bradley	1952	Acting President
21		Donald S. Russell	1952–1957
22		Robert Llewellyn Sumwalt	1957–1962	Acting President from 1957 to 1959
23		Thomas F. Jones	1962–1974
24		William H. Patterson	1974–1977
25		James B. Holderman	1977–1990
–		Arthur K. Smith	1990–1991	Interim President
26		John M. Palms	1991–2002
27		Andrew A. Sorensen	2002–2008
28		Harris Pastides	2008–2019
29		Robert L. Caslen	2019–2021
–		Harris Pastides	2021–2022	Interim President; 2nd time
30		Michael Amiridis	July 1, 2022	Incumbent