The following is a list of state highways in Missouri. State highways in Missouri are the responsibility of the Missouri Department of Transportation.

Mainline routes

Number	Length (mi)	Length (km)	Southern or western terminus	Northern or eastern terminus	Formed	Removed	Notes
Route 1	7.253	11.673	Route 210 in North Kansas City	Route 152 in Kansas City	01922-01-011922	current
Route 2	—	—	—	—	01922-01-011922	01926-01-011926
Route 2	69.478	111.814	K-68 at the Kansas state line	Route 52 in Windsor	01926-01-011926	current
Route 3	—	—	—	—	01922-01-011922	01926-01-011926
Route 3	73.738	118.670	Route 5 / Route 240 near Fayette	Route 11 near Kirksville	01926-01-011926	current
Route 4	102	164	US 136 at the Nebraska state line.	US 169 at the Iowa state line.	01922-01-011922	01960-01-011960
Route 5	352.834	567.831	AR 5 at the Arkansas state line	Iowa 5 at the Iowa state line	01922-01-011922	current
Route 6	208.551	335.630	I-29 BL / US 169 in St. Joseph	US 24 / US 61 near Taylor	01922-01-011922	current
Route 7	—	—	—	—	01922-01-011922	01926-01-011926
Route 7	186.476	300.104	I-44 near Laquey	US 24 near Independence	01926-01-011926	current
Route 8	—	—	—	—	01922-01-011922	01926-01-011926
Route 8	72.059	115.968	I-44 / Route 8 in St. James	US 67 in Desloge	01926-01-011926	current
Route 9	—	—	—	—	01922-01-011922	01926-01-011926
Route 9	—	—	—	—	01926-01-011926	01935-01-011935
Route 9	14.273	22.970	I-35 / I-70 / US 24 / US 40 in Kansas City	I-29 / US 71 in Kansas City	01934-01-011934	current
Route 10	47.780	76.894	US 69 in Excelsior Springs	US 24 / US 65 near Carrollton	01922-01-011922	current
Route 11	—	—	—	—	01922-01-011922	01926-01-011926
Route 11	100.176	161.218	US 24 near Brunswick	Route 15 near Baring	01929-01-011929	current
Route 12	—	—	—	—	01922-01-011922	01926-01-011926
Route 12	—	—	—	—	01926-01-011926	—
Route 12	—	—	—	—	01934-01-011934	—
Route 12	—	—	—	—	01939-01-011939	—
Route 12	3.787	6.095	I-435 in Kansas City	Spring Street in Independence	01950-01-011950	current
Route 13	290.608	467.688	AR 21 at the Arkansas state line	US 69 / US 136 in Bethany	01922-01-011922	current
Route 14	—	—	—	—	01922-01-011922	01926-01-011926
Route 14	119.932	193.012	US 60 in Marionville	US 63 near West Plains	01926-01-011926	current
Route 15	121.249	195.131	US 54 in Mexico	CR V56 at the Iowa state line	01922-01-011922	current
Route 16	—	—	—	—	01922-01-011922	01930-01-011930
Route 16	—	—	—	—	01935-01-011935	01941-01-011941
Route 16	16.709	26.891	Route 6 near Lewistown	US 61 Bus. in Canton	01941-01-011941	current
Route 17	186.870	300.738	AR 395 at the Arkansas state line	US 54 near Eldon	01922-01-011922	current
Route 18	—	—	—	—	01922-01-011922	01932-01-011932
Route 18	—	—	—	—	01932-01-011932	01934-01-011934
Route 18	56.054	90.210	CR 259 at the Kansas state line	Route 7 / Route 13 / Route 52 in Clinton	—	—
Route 19	264.909	426.330	US 63 in Thayer	US 61 near New London	01922-01-011922	current
Route 20	31.609	50.870	Route 13 near Higginsville	US 65 Bus. in Marshall	01922-01-011922	current
Route 21	194.127	312.417	AR 115 at the Arkansas state line	Route 30 in Affton	01922-01-011922	current
Route 22	28.797	46.344	US 63 near Clark	US 54 / Route 15 near Mexico	01922-01-011922	current
Route 23	49.880	80.274	Route 2 near Windsor	US 24 near Waverly	—	—
Route 24	—	—	—	—	01922-01-011922	01926-01-011926
Route 25	91.180	146.740	US 412 / Route 84 in Kennett	I-55 BL / US 61 / Route 34 / Route 72 in Jackson	01922-01-011922	current
Route 26	—	—	—	—	01922-01-011922	01927-01-011927
Route 26	—	—	—	—	01927-01-011927	—
Route 26	—	—	—	—	01950-01-011950	—
Route 27	—	—	—	—	01922-01-011922	01969-01-011969
Route 27	7.387	11.888	US 61 near Wayland	Iowa 27 at the Iowa state line	02004-01-012004	current	Avenue of the Saints
Route 28	71.267	114.693	I-44 near St. Robert	US 50 in Rosebud	01922-01-011922	current
Route 29	—	—	—	—	01922-01-011922	01930-01-011930
Route 29	—	—	—	—	01935-01-011935	—
Route 30	52.718	84.841	I-44 in St. Clair	I-44 / I-55 in St. Louis	01922-01-011922	current
Route 31	26.852	43.214	US 169 near Gower	US 169 near Union Star	01922-01-011922	current
Route 32	282.838	455.184	US 54 in El Dorado Springs	Fourth Street in Ste. Genevieve	01922-01-011922	current
Route 33	54.980	88.482	Route 291 in Liberty	Route 6 in Maysville	01922-01-011922	current
Route 34	103.378	166.371	US 60 / Route 21 near Van Buren	IL 146 at the Illinois state line	01922-01-011922	current
Route 35	—	—	—	—	01922-01-011922	—
Route 36	—	—	—	—	01922-01-011922	01926-01-011926
Route 37	78.683	126.628	AR 37 at the Arkansas state line	US 160 / Route 126 in Golden City	01922-01-011922	current
Route 38	—	—	—	—	01922-01-011922	01938-01-011938
Route 38	80.561	129.650	US 65 near Buffalo	Route 17 near Houston	01940-01-011940	current
Route 39	111.251	179.041	AR 221 at the Arkansas state line	US 54 at Cedar Springs	01922-01-011922	current
Route 40	—	—	—	—	01922-01-011922	01926-01-011926
Route 41	45.981	73.999	I-70 / US 40 / Route 135 near Boonville	US 24 near Brunswick	01922-01-011922	current
Route 42	—	—	—	—	01922-01-011922	—
Route 42	60.410	97.220	US 54 in Osage Beach	Route 28 near Belle	—	—
Route 43	—	—	—	—	01922-01-011922	—
Route 43	98.366	158.305	SH-20 / AR 43 at the Oklahoma–Arkansas–Missouri tripoint	US 54 near Nevada	—	—
Route 44	—	—	—	—	01922-01-011922	—
Route 45	—	—	—	—	01922-01-011922	—
Route 45	36.920	59.417	I-29 / US 71 in Kansas City	US 59 / Route 273 in Lewis and Clark Village	—	—
Route 46	86	138	US 59 east of Fairfax	US 69 north of Eagleville	01922-01-011922	current
Route 47	117	188	US 67 in Bonne Terre	Route 79 in Winfield	01922-01-011922	current
Route 48	20.128	32.393	US 71 north of Savannah	US 169 in King City	01922-01-011922	current
Route 49	120	190	US 67 north of Poplar Bluff	Route 19 in Cherryville	01922-01-011922	current
Route 50	—	—	—	—	01922-01-011922	01926-01-011926
Route 51	116	187	AR 139 at the Arkansas state line	IL 150 at the Illinois state line	01922-01-011922	current
Route 52	—	—	—	—	01922-01-011922	01926-01-011926
Route 52	173	278	K-52 at the Kansas state line	Route 133 east of St. Elizabeth	01926-01-011926	current
Route 53	33	53	Route 25 in Holcomb	U.S. Route 160 / US 67 Bus. in Poplar Bluff	01922-01-011922	current
Route 54	—	—	—	—	01922-01-011922	01927-01-011927
Route 55	—	—	—	—	01922-01-011922	—
Route 56	—	—	—	—	01922-01-011922	01929-01-011929
Route 56	—	—	—	—	01929-01-011929	01957-01-011957
Route 57	—	—	—	—	01922-01-011922	—
Route 58	50	80	Route D west of Belton	US 50 west of Warrensburg	01922-01-011922	current
Route 59	—	—	—	—	01922-01-011922	01935-01-011935
Route 59	45	72	AR 59 at the Arkansas state line	I-44 / I-49 / US 71 in Fidelity	—	—
Route 60	—	—	—	—	01922-01-011922	01926-01-011926
Route 61	—	—	—	—	01922-01-011922	01926-01-011926
Route 62	—	—	—	—	01922-01-011922	01926-01-011926
Route 62	—	—	—	—	01927-01-011927	—
Route 63	—	—	—	—	01922-01-011922	01926-01-011926
Route 64	51.290	82.543	Route 254 near Hermitage	Route 5 in Lebanon	01922-01-011922	current
Route 65	—	—	—	—	01922-01-011922	01925-01-011925
Route 66	14.239	22.915	K-66 at the Kansas state line	I-44 / I-44 BL / I-49 east of Duenweg	—	—	Part of Historic US 66
Route 67	—	—	—	—	01922-01-011922	01926-01-011926
Route 68	37	60	US 63 north of Rolla	Route 19 in Salem	—	—
Route 69	—	—	—	—	01922-01-011922	01925-01-011925
Route 70	—	—	—	—	01922-01-011922	—
Route 71	—	—	—	—	01922-01-011922	01923-01-011923
Route 72	157	253	I-44 BL in Rolla	I-55 BL / US 61 / Route 25 in Jackson	01922-01-011922	current
Route 73	20.034	32.242	US 65 in Buffalo	US 54 near Macks Creek	01933-01-011933	current
Route 73	—	—	—	—	01929-01-011929	—
Route 74	9	14	Route 25 in Dutchtown	IL 146 at the Illinois state line	01922-01-011922	current
Route 75	5.567	8.959	Route 80 east of East Prairie	Route 105 west of Anniston	01968-01-011968	current
Route 75	—	—	—	—	01929-01-011929	—
Route 76	189	304	Oklahoma state line near / Tiff City	US 60 / US 63 / Route 137 at Willow Springs	01922-01-011922	current
Route 77	65	105	KY 1354 via Dorena-Hickman Ferry	Route 25 south of Dutchtown	—	—
Route 77	—	—	—	—	01929-01-011929	—
Route 78	12	19	I-435 in Kansas City	Route 7 east of Independence	—	—
Route 78	—	—	—	—	01922-01-011922	—
Route 79	86	138	I-70 in St. Peters	I-72 / US 36 / Route 110 in Hannibal	—	—
Route 80	27.302	43.938	US 61 / US 62 south of Sikeston	Dead end at the Mississippi River in Belmont	—	—	Used to end at Belmont-Columbus Ferry but closed
Route 80	—	—	—	—	01922-01-011922	—
Route 81	40.954	65.909	Route 16 west of Canton	Iowa 81 at the Iowa state line	—	—
Route 82	—	—	—	—	01922-01-011922	—
Route 82	39	63	US 54 in El Dorado Springs	Route 83 east of Osceola	—	—
Route 83	55	89	Route 13 in Bolivar	US 65 / Route 7 at Warsaw	01929-01-011929	current
Route 84	30.215	48.626	AR 90 at Arkansas state line	I-155 / US 412 in Caruthersville	01922-01-011922	current
Route 85	3.414	5.494	Route A in Evona	US 136 in Albany	01929-01-011929	current
Route 86	110.324	177.549	I-44 / I-44 BL / Route 43 in Joplin	US 65 in Ridgedale	01922-01-011922	current
Route 87	77	124	US 54 in Eldon	Route 5 / Route 240 in Glasgow	01929-01-011929	current
Route 88	—	—	—	—	01922-01-011922	—
Route 88	6.847	11.019	US 60 / US 160 in Springfield	I-44 BL / US 65 Bus. in Springfield	—	—
Route 89	38.737	62.341	Route 28 in Belle	Route 100 in Chamois	01929-01-011929	current
Route 90	46.561	74.933	Route 43 north of Southwest City	Route 37 in Washburn	01922-01-011922	current
Route 91	28.765	46.293	US 61 in Morley	Route 51 in Advance	01929-01-011929	current
Route 92	39.594	63.720	K-92 at the Kansas state line	US 69 in Excelsior Springs	01922-01-011922	current
Route 93	—	—	—	—	01929-01-011929	—
Route 94	136.297	219.349	US 63 / US 54 in Jefferson City	US 67 in West Alton	01922-01-011922	current
Route 95	93.051	149.751	US 160 at Lutie	Route 32 at Lynchburg	01929-01-011929	current
Route 96	—	—	—	—	01922-01-011922	01922-01-011922
Route 96	—	—	—	—	01929-01-011929	01941-01-011941
Route 96	52	84	Route 171 north of Carl Junction	I-44 west of Halltown	01941-01-011941	current	Part of Historic US 66
Route 97	74	119	Route 86 north of Wheaton	Route 32 south of El Dorado Springs	01929-01-011929	current
Route 98	8.376	13.480	Route 87 in Boonville	Cumberland Church Road in Overton	01922-01-011922	current
Route 99	14.9	24.0	Route 30 in St. Louis	US 66 / US 67 / US 40 Byp. in Bellefontaine Neighbors	01929-01-011929	—	Former highway bypassing Downtown St. Louis[1]
Route 99	18.3	29.5	US 160 east of West Plains	US 60 in Birch Tree	—	—
Route 100	121.144	194.962	US 50 in Linn	3rd Street in St. Louis	01929-01-011929	current
Route 101	11.626	18.710	AR 101 at the Arkansas state line	US 160 in Caulfield	01941-01-011941	current
Route 101	—	—	—	—	01929-01-011929	—
Route 102	17.349	27.921	Route 105 near East Prairie	Route 77 in Dorena	—	—
Route 102	—	—	—	—	01929-01-011929	—
Route 103	3.832	6.167	Route Z in the Big Spring Historic District	US 60 near Van Buren	01929-01-011929	current	unlabeled until 1933
Route 104	3.206	5.160	Route 21 in Washington State Park	Route 21 in Washington State Park	—	—
Route 104	—	—	—	—	01929-01-011929	—
Route 105	10.534	16.953	Route 80 in East Prairie	I-57 BL / US 62 / Route 77 in Charleston	01929-01-011929	current
Route 106	48	77	Route 17 in Summersville	Route 21 in Ellington	01929-01-011929	current
Route 107	8.792	14.149	Route 154 in Mark Twain State Park	US 24 southwest of Monroe City	01929-01-011929	current
Route 108	5.709	9.188	AR 77 in Arkmo	US 412 near Arbyrd	01929-01-011929	current
Route 109	13.128	21.127	Route W / Route FF in Jefferson County	Route CC in Chesterfield	—	—
Route 109	—	—	—	—	01929-01-011929	—
Route 110 (CKC)	199.561	321.162	I-35 / I-435 in Claycomo	US 36 / I-72 / IL 110 in Hannibal	02012-01-012012	current	Chicago–Kansas City Expressway
Route 110	6.385	10.276	Route 21 near De Soto	US 67 near De Soto	01929-01-011929	current
Route 111	46.108	74.204	US 59 in Oregon	US 136 in Rock Port	—	—
Route 111	—	—	—	—	01929-01-011929	—
Route 112	17.516	28.189	Route 37 in Seligman	Route 37 / Route 76 / Route 86 in Cassville	01929-01-011929	current
Route 113	26	42	US 59 near Mound City	US 136 in Burlington Junction	01929-01-011929	current
Route 114	21	34	Route 25 in Dexter	US 61 / US 62 / US 60 Bus. in Sikeston	—	—
Route 114	—	—	—	—	01929-01-011929	—
Route 115	10.255	16.504	I-70 in Berkeley	I-70 in St. Louis	—	—	Locally known as Natural Bridge Road
Route 115	—	—	—	—	01929-01-011929	—
Route 116	68	109	US 59 in Rushville	Route A in Braymer	01929-01-011929	current
Route 117	0.260	0.418	End of state maintenance at Indian Trail Conversation Area	Route 19 near Salem	01929-01-011929	current
Route 118	6.801	10.945	Route 111 near Bigelow	US 59 in Mound City	—	—
Route 118	—	—	—	—	01929-01-011929	—
Route 119	10	16	Montauk State Park entrance	Route 32 in Salem	01929-01-011929	current
Route 120	3.132	5.040	US 59 near Oregon	Route B near New Point	01929-01-011929	current
Route 121	1.258	2.025	US 69 near Cameron	Route HH in Wallace State Park	—	—
Route 122	4.936	7.944	VM Pinnacle Drive in Van Meter State Park	Route 41 near Marshall	—	—
Route 123	45.889	73.851	US 160 in Willard	US 54 in Weaubleau	—	—
Route 124	36	58	Route 240 near Fayette	Route 22 / Route 151 in Centralia	—	—
Route 125	78	126	AR 125 at the Arkansas state line	US 65 in Fair Grove	—	—
Route 126	29.226	47.035	K-126 at the Kansas state line	US 160 / Route 37 in Golden City	01942-01-011942	current
Route 127	51	82	Route 52 near Sedalia	US 65 near Malta Bend	—	—
Route 128	1.215	1.955	Route 146 nearTrenton	Crowder State Park	—	—
Route 129	116	187	Route 3 in Roanoke	CR T20 at the Iowa state line	—	—
Route 130	6.20	9.98	Route 139 in Laclede	US 36 / Route 139 near Laclede	—	—
Route 131	38	61	Route 2 near Medford	Route 224 in Wellington	—	—
Route 132	—	—	—	—	—	—
Route 133	67	108	I-44 near Waynesville	US 63 near Westphalia	—	—
Route 134	5.071	8.161	Entrance to Lake of the Ozarks State Park	Route 42 near Osage Beach	—	—
Route 135	70	110	Route 5 near Sunrise Beach	I-70 / US 40 / Route 41 near Boonville	—	—
Route 136	—	—	—	—	—	01951-01-011951
Route 137	44	71	US 60 / US 63 / Route 76 in Willow Springs	Route 32 in Licking	—	—
Route 138	1.112	1.790	Lakeshore Drive in Lewis and Clark State Park	Route 45 / Route 273 near Iatan	—	—
Route 139	107	172	US 24 near Carrollton	CR S40 at the Iowa state line	—	—
Route 140	—	—	—	—	—	—
Route 141	30.902	49.732	US 61 / US 67 in Arnold	Route 370 in Bridgeton	—	—
Route 142	130	210	Route 101 in Bakersfield	Route 53 in Poplar Bluff	—	—
Route 143	17.507	28.175	Route 34 near Patterson	Route 49 in Des Arc	—	—
Route 144	2.956	4.757	Route 32 in Millers	Bauer Road / Park Drive at Hawn State Park	—	—
Route 144	—	—	—	—	—	—
Route 145	3.148	5.066	—	—	—	—
Route 146	28	45	US 136 near Princeton	Route B near Princeton	—	—
Route 147	2.333	3.755	US 136 near Bethany	Route 6 near Trenton	—	—
Route 148	14.38	23.14	—	—	—	—
Route 148	—	—	—	—	—	—
Route 148	—	—	—	—	—	—
Route 149	84	135	—	—	—	—
Route 150	25.666	41.305	—	—	—	—
Route 151	67	108	—	—	—	—
Route 152	16.875	27.158	—	—	—	—
Route 153	45	72	—	—	—	—
Route 154	36	58	—	—	—	—
Route 155	—	—	—	—	—	—
Route 156	58	93	—	—	—	—
Route 157	2.721	4.379	—	—	—	—
Route 158	5.368	8.639	—	—	—	—
Route 161	42.299	68.074	—	—	—	—
Route 162	29.767	47.905	—	—	01956-01-011956[2]	current
Route 163	14.323	23.051	—	—	—	—
Route 164	38.71	62.30	—	—	01956-01-011956[2]	current
Route 165	12.4	20.0	—	—	—	—
Route 168	43	69	—	—	01956-01-011956	current
Route 170	—	—	—	—	—	—
Route 171	26	42	I-49 / US 71 / Route 96 / Route 571 in Carthage	Kansas state line at Opolis, Kansas	—	—
Route 172	8.97	14.44	—	—	—	—
Route 173	9.260	14.903	—	—	—	—
Route 174	20	32	Route 39 in Mount Vernon	US 60 / Route 413 in Republic	—	—
Route 175	6.502	10.464	—	—	—	—
Route 175	—	—	—	—	—	—
Route 176	32	51	—	—	—	—
Route 177	23.489	37.802	—	—	—	—
Route 178	—	—	—	—	—	—
Route 179	43	69	—	—	—	—
Route 180	13.895	22.362	Pennridge Drive in Bridgeton	Page Boulevard / Route D in St. Louis	—	—
Route 181	55	89	—	—	—	—
Route 185	65	105	—	—	—	—
Route 187	2.218	3.570	—	—	—	—
Route 190	36	58	—	—	—	—
Route 202	8.546	13.753	—	—	—	—
Route 210	35	56	—	—	—	—
Route 213	6.943	11.174	—	—	—	—
Route 215	51	82	—	—	—	—
Route 221	16.317	26.260	—	—	—	—
Route 224	13	21	—	—	—	—	Missouri Scenic Byway
Route 231	12.234	19.689	River City Casino Boulevard at the St. Louis city–county line	Jeffco Boulevard / US 61 / US 67 in Arnold	—	—
Route 240	52	84	—	—	—	—
Route 242	2.304	3.708	—	—	—	—
Route 245	16.833	27.090	—	—	—	—
Route 246	15.002	24.143	—	—	—	—
Route 248	55	89	Route 76 / Route 86 / Route 112 in Cassville	US 65 / US 65 Bus. in Branson	—	—
Route 249	6.162	9.917	—	—	—	—
Route 254	10.247	16.491	—	—	—	—
Route 265	66	106	—	—	—	—
Route 266	16.237	26.131	Route 96 west of Halltown	I-44 / I-44 BL in Springfield	—	—	Part of Historic US 66
Route 266	—	—	—	—	—	—
Route 267	4.027	6.481	River City Casino Boulevard at the St. Louis city–county line	US 61 / US 67 near Mehlville	—	—
Route 269	3.320	5.343	Front Street in Kansas City	I-35 in Kansas City	—	—
Route 271	—	—	—	—	—	—
Route 273	22	35	Route 92 in Tracy	US 59 / Route 45 at the Kansas state line	—	—
Route 283	2.2	3.5	Route 9 in North Kansas City	I-29 / US 71 in Kansas City	—	—
Route 291	49.431	79.551	I-49 / US 71 in Harrisonville	I-435 in Kansas City	—	—
Route 340	19.726	31.746	Route 100 / Manchester Road in Ellisville	Skinker Boulevard in St. Louis	—	—
Route 350	8.589	13.823	55th Street in Kansas City	I-470 / US 50 in Lee's Summit	—	—
Route 354	—	—	—	—	01968-01-011968	01969-01-011969
Route 360	4	6.4	I-44 west of Springfield	US 60 / Route 413 near Springfield–Republic city limits	—	—	Part of James River Freeway
Route 364	21.384	34.414	I-64 / US 40 / US 61 in Lake St. Louis	I-270 in Maryland Heights	—	—
Route 366	12.000	19.312	Route 30 / Gravois Road in St. Louis	I-44 / US 50 at S. Geyer Road in Sunset Hills	—	—	Part of Historic US 66
Route 367	8.960	14.420	I-70 in St. Louis	US 67 in Spanish Lake	—	—
Route 370	12.957	20.852	I-70 in St. Peters	I-270 in Bridgeton	—	—
Route 371	25	40	Route 273 / I-29 in Tracy	I-29 BL in St. Joseph	—	—
Route 376	1.739	2.799	Route 76 in Branson	Route 265 in Branson	—	—
Route 413	48.745	78.447	Route 13 / Route 76 / Route 265 in Reeds Spring	Route 13 in Springfield	—	—
Route 465	—	—	—	—	02003-01-012003	02020-01-012020
Route 571	4.484	7.216	I-49 / US 71	I-49 / US 71 / Route 96 / Route 171	—	—
Route 725	—	—	—	—	—	—
Route 740	6.329	10.186	I-70 / US 40 / Route E in Columbia	Maguire Boulevard in Columbia	—	—
Route 744	11.331	18.235	Springfield-Branson Airport in Springfield	I-44 in Springfield	—	—	Part of Historic US 66
Route 750	—	—	—	—	—	—
Route 752	3.113	5.010	US 59 / Route U in St. Joseph	I-229 in St. Joseph	—	—
Route 755	—	—	—	—	—	—
Route 759	2.126	3.421	Southwest Lower Lake Road in St. Joseph	I-229 / US 59 in St. Joseph	—	—
Route 763	6.771	10.897	Route 740 in Columbia	US 63 north of Columbia	—	—
Route 765	2.635	4.241	US 65 in Sedalia	US 65 in Sedalia	01966-01-011966	current
Route 769	—	—	—	—	01960-03-221960	—	A proposed state highway[citation needed]
Route 799	0.50	0.80	—	—	—	—	An unsigned designation for the Martin Luther King Jr. Memorial Bridge in St. Louis

Special routes

Number	Length (mi)[3]	Length (km)	Southern or western terminus	Northern or eastern terminus	Serves	Formed	Removed	Notes
Route 1A	—	—	—	—		—	—
Route 1B	—	—	—	—		—	—
Route 1C	—	—	—	—		—	—
Route 1D	—	—	—	—		—	—
Route 1E	—	—	—	—		—	—
Route 1F	—	—	—	—		—	—
Route 1F	—	—	—	—		—	—
Route 4A	—	—	—	—		—	—
Route 4B	14.6	23.5	—	—		—	—
Route 5A	—	—	—	—		—	—
Route 5 Bus.	2.461	3.961	Route 5 / Route 76 south of Ava	Route 5 / Route 14 / Route 76 at Ava	Ava	—	—
Route 5 Bus.	4.94	7.95	—	—	Camdenton	—	—
Route 5 Bus.	2.646	4.258	Route 5 / Route 6 southwest of Milan	Route 5 / Route 6 at Milan	Milan	—	—
Route 7 Bus.	1.671	2.689	Route 7 / Route 58 at Pleasant Hill	Route 7 in Pleasant Hill	Pleasant Hill	—	—
Route 9A	—	—	—	—		—	—
Route 10 Bus.	5.410	8.707	Route 10 west of Richmond	Route 10 east of Richmond	Richmond	—	—
Route 12A	—	—	—	—		—	—
Route 12B	—	—	—	—		—	—
Route 13 Bus.	3.147	5.065	Route 13 / Route 123 south of Humansville	Route 13 at Humansville	Humansville	—	—
Route 13 Bus.	5.049	8.126	Route 13 / Route 83 at Bolivar	Route 13 / Route 32 at Bolivar	Bolivar	—	—
Route 13 Bus.	8.301	13.359	Route 13 south of Warrensburg	Route 13 north of Warrensburg	Warrensburg	—	—
Route 13 Bus.	2.05	3.30	—	—	Branson West	—	—
Route 13 Bus.	3.53	5.68	—	—	Clinton	—	—
Route 13 Bus.	2.81	4.52	—	—	Collins	—	—
Route 13 Bus.	4.22	6.79	—	—	Higginsville	—	—
Route 13 Bus.	6.635	10.678	Route 13 southeast of Lexington	US 24 / Route 13 at Lexington	Lexington	—	—
Route 13 Spur	0.362	0.583	Route 224 in Lexington	Battle of Lexington State Historic Site	Battle of Lexington State Historic Site	—	—
Route 13 Bus.	1.895	3.050	Route 82 at Osceola	Route 13 at Osceola	Osceola	—	—
Route 13 Bus.	1.564	2.517	Route 13 at Richmond	Route 10 Bus. / Route 13 in Richmond	Richmond	—	—
Route 15 Spur	1.28	2.06	—	—	Paris	—	—
Route 17A	5.01	8.06	—	—	Plato	—	—
Route 19A	—	—	—	—		—	—
Route 21A	—	—	—	—		—	—
Route 21 Alt.	5.22	8.40	Route 21 in DeSoto	Route 21 in DeSoto	DeSoto	—	—
Route 21 Bus.	2.49	4.01	—	—	Hillsboro	—	—
Route 25 Bus.	3.231	5.200	US 62 / Route 25 at Malden	Route 25 at Malden	Malden	—	—
Route 32 Bus.	3.148	5.066	Route 32 at Park Hills	Route 32 at Park Hills	Park Hills	—	—
Route 33A	—	—	—	—		—	—
Route 34 Spur	0.89	1.43	—	—	Jackson	—	—
Route 37 Bus.	1.69	2.72	—	—	Butterfield	—	—
Route 37 Bus.	4.612	7.422	Route 37 / Route 76 / Route 86 / Route 112 at Cassville	Route 37 north of Cassville	Cassville	—	—
Route 37 Bus.	2.44	3.93	—	—	Purdy	—	—
Route 37 Bus.	1.845	2.969	Route 37 at Seligman	Route 37 at Seligman	Seligman	—	—
Route 38N	—	—	—	—		—	—
Route 39 Bus.	2.164	3.483	I-44 BL / Route 39 at Mount Vernon	Route 39 / Route 174 at Mount Vernon	Mount Vernon	—	—
Route 41 Spur	0.410	0.660	Route 41 at Arrow Rock	Main Street in Arrow Rock	Arrow Rock	—	—
Route 41 Spur	0.666	1.072	Route 41 at Miami	Wall Street in Miami	Miami	—	—
Route 43 Truck	1.97	3.17	US 60 at Seneca	MO 43 at Seneca	Seneca	—	—	Route 43 Truck bypasses a steep grade just south of Seneca.
Route 49A	—	—	—	—		—	—
Route 51A	—	—	—	—		—	—
Route 52A	—	—	—	—		—	—
Route 52 Bus.	1.890	3.042	Route 52 at Deepwater	Route 13 / Route 52 near Deepwater	Deepwater	—	—
Route 54A	—	—	—	—		—	—
Route 55A	—	—	—	—		—	—
Route 58 Spur	0.257	0.414	Main Street in Centerview	Route 58 at Centerview	Centerview	—	—
Route 64A	—	—	—	—		—	—
Route 64A	1.509	2.429	Bennett Springs State Park Road 22	Route 64		—	—
Route 64B	2.257	3.632	Pomme de Terre State Park	Route 64		—	—
Route 76A	—	—	—	—		—	—
Route 84 Spur	0.291	0.468	Route 84 at Caruthersville	3rd Street in Caruthersville	Caruthersville	—	—
Route 89 Spur	1.620	2.607	US 50 east of Potts	Route 89 northeast of Potts	Osage County	—	—	Commonly referred to as Route 89Y as well
Route 92 Spur	0.217	0.349	Route 273 at Tracy	Route 92 in Tracy	Tracy	—	—	Runs concurrently with Spur 273
Route 106 Spur	1.359	2.187	Deer Run State Forest	Route 106 west of Ellington	Deer Run State Forest	—	—
Route 111 Spur	0.561	0.903	Route 111 in Craig	US 59 in Craig	Craig	—	—
Route 112 Spur	0.381	0.613	Route 112 south of Cassville	Roaring River State Park	Roaring River State Park	—	—
Route 124 Bus.	0.991	1.595	Route 124 at Centralia	Route 22 at Centralia	Centralia	—	—
Route 180 Spur	0.867	1.395	Route D in Pagedale	Route 180 in Pagedale	Pagedale	—	—
Route 185 Spur	2.211	3.558	Route 185 east of Sullivan	Meramec State Park	Meramec State Park	—	—
Route 215 Spur	0.267	0.430	Route 13 / Route 215 near Brighton	Route F near Brighton	Brighton	—	—
Route 240 Alt.	0.789	1.270	US 40 west of Rocheport	Route 240 northwest of Rocheport	Howard County	—	—
Route 240 Bus.	4.858	7.818	Route 5 / Route 87 / Route 240 in Glasgow	Route 5 / Route 240 east of Glasgow	Glasgow	—	—
Route 240 Spur	1.091	1.756	3rd Street in Rocheport	US 40 north of Rocheport	Rocheport	—	—
Route 269 Temp.	—	—	—	—	Kansas City	01956-01-011956	01957-01-011957
Route 273 Spur	0.217	0.349	Route 273 at Tracy	Route 92 in Tracy	Tracy	—	—	Runs concurrently with Spur 92

Former

This is a list of former highways as assigned in 1922. All numbers from Route 1 to Route 72 were issued. From Route 72 to Route 98, only even numbers were issued.

In 1926, the U.S. Highway System was created and many of the highways listed below became part of a new U.S. Highway; in some cases, a highway's number was changed so as not to conflict with a U.S. Highway number (or, later, an Interstate Highway number) which came through Missouri.

• Route 1, Arkansas to Iowa via Kansas City: still exists near Kansas City
  • Route 1A, Rock Port to Phelps City: became US 136
  • Route 1B, branch to Craig: not built, since Route 1 (US 59) was routed through Craig
  • Route 1C, Mound City to Bigelow: became Route 118
  • Route 1D, Mound City to Skidmore: became Route 113
  • Route 1E, branch to New Point: became Route 120
  • Route 1F, Oregon to Forest City: became Route 111
  • Route 1F, Joplin to Kansas: became US 66
• Route 2, Kansas City to St. Louis via Columbia: became US 40
• Route 3, Arkansas to Iowa via Springfield: became US 65
• Route 4, St. Joseph to Alexandria: became US 136
  • Route 4A, Albany to Evona: became Route 85
• Route 5, Arkansas to Iowa via Boonville: still exists
  • Route 5A, Wasola to Longrun: became Route 95
• Route 6, St. Joseph to Canton: still exists
• Route 7, Arkansas to Iowa via Jefferson City: became US 63
• Route 8, St. Joseph to Hannibal: became US 36
• Route 9, Arkansas to Iowa via St. Louis: became US 61 and Route 4B, which became Route 81
  • Route 9A, Palmyra to Philadelphia: became Route 56; became Route 168 US 56 came into the state
• Route 10, Kansas City to Monroe City: still exists west of Carrollton
• Route 11, Kansas City to Iowa: became US 69
• Route 12, Kansas City to St. Louis via Jefferson City: became US 50
  • Route 12A, California to Jamestown: became Route 87
  • Route 12B, Linn to Chamois: became Route 89
• Route 13, Bolivar to Gallatin: still exists
• Route 14, Carthage to St. Louis: became US 66
• Route 15, Buffalo to Iowa via Jefferson City: still exists north of Mexico
• Route 16, Oklahoma to Kentucky via Springfield: became US 60
• Route 17, Mountain View to Eugene: still exists^[4]
• Route 18, Tarkio to Stanberry: became US 136
• Route 19, Thayer to Cuba: still exists
• Route 20, Kansas City to Huntsville: still exists (realigned) west of Marshall
• Route 21, Arkansas to De Soto: still exists
• Route 22, Clark to Illinois: still exists west of Mexico
• Route 23, Arkansas to Fredericktown: became US 67
• Route 24, Kansas to Tuscumbia: became Route 52
• Route 25, Arkansas to Festus: still exists south of Jackson
• Route 26, Kansas to Osceola: became Route 62; became Route 82 when US 62 came into the state
• Route 27, Savannah to Iowa: became US 71 and Route 148
• Route 28, Waynesville to Rosebud: still exists
• Route 29, Stanberry to Iowa: became US 169
• Route 30, St. Clair to St. Louis: still exists
• Route 31, Clarksdale to King City: still exists
• Route 32, Licking to Flat River: still exists
• Route 33, Kansas City to Osborn: still exists
  • Route 33A, Plattsburg to Lathrop: became Route 116
• Route 34, Garwood to Jackson: still exists
• Route 35, Harrisonville to Kansas City: swapped with US 71 and later became Route 291
• Route 36, Kansas to Springfield: became US 160
• Route 37, Arkansas to Monett: still exists
• Route 38, Carthage to Republic: became Route 14 and later became US 166
• Route 39, Pennsboro to Stockton: still exists
• Route 40, Billings to near West Plains: became Route 14
• Route 41, Lamine to De Witt: still exists
• Route 42, Alton to Poplar Bluff: became Route 14 and later became US 160
• Route 43, Arkansas to Marionville: became Route 13
• Route 44, Anderson to Spokane: became Route 76
• Route 45, Drake to Martinsburg: became Route 19
• Route 46, through Grant City: still exists
• Route 47, Villa Ridge to Troy: still exists
• Route 48, Rosendale to King City: still exists
• Route 49, Piedmont to Glover: still exists
• Route 50, St. Joseph to Grayson: became US 169
• Route 51, Advance to Illinois: still exists
  • Route 51A, Dongola to Puxico: became Route 51
• Route 52, Kansas to St. Joseph: became US 59
  • Route 52A, branch to Lewis and Clark Lake: became Route 45
• Route 53, Kennett to Poplar Bluff: still exists
• Route 54, Paris to New London: became Route 26; now Routes 154 and 19
  • Route 54A, Perry to Hutchison: became Route 19
• Route 55, Wolf Island to Benton: became Route 77
  • Route 55A, Charleston to East Prairie: became Route 105
• Route 56, Troy to O'Fallon: became Routes 47 and 79
• Route 57, Webb City to Kansas: became Route 171
• Route 58, Pleasant Hill to Warrensburg: still exists
• Route 59, Kansas City to Platte City: became Route 9
• Route 60, Leeton to Windsor: became Route 2
• Route 61, Tarkio to Iowa: became Route 9 and later became US 59
• Route 62, Steelville to Potosi: became Route 8
• Route 63, Harrisonville to Lees Summit: became Route 7
• Route 64, Collins to Preston: still exists east of Hermitage
  • Route 64A, Wheatland to Quincy: became Route 83
• Route 65, St. James to Hawkins Store: became Route 68
• Route 66, El Dorado Springs to Fair Play: became US 54; now Route 32
• Route 67, Rocheport to Fayette: became Route 3; now Route 240
• Route 68, Farmington to Sainte Genevieve: became Route 32
• Route 69, Springfield to Bolivar: became Route 13
• Route 70, Ironton to Fredericktown: became Route 72
• Route 71, Springfield to Preston: absorbed by Route 3 (US 65) when its portion here was not built
• Route 72, Salem to Centerville: still exists
• Route 74, Dutchtown to Cape Girardeau: still exists
• Route 76, Spokane to Forsyth: swapped with Route 80 (now US 160); still exists
• Route 78, Branson to Brownbranch: became Route 76 and Route 80 (this section later became part of Route 76)
• Route 80, Gainesville to West Plains: became US 160
• Route 82, Malden to New Madrid: became US 62
• Route 84, Arkansas to Caruthersville: still exists
• Route 86, Blue Eye to Hollister: still exists
• Route 88, Lanagan to Arkansas: became US 71 when Route 59 was formed
• Route 90, Oklahoma to Noel: still exists
• Route 92, Kansas to Smithville: still exists
• Route 94, St. Charles to West Alton: still exists^[5]
• Route 96, Odessa to Marshall: not built, but now partly Route 20
• Route 98, Boonville to Overton: still exists