Little River may refer to the following rivers in the U.S. state of South Carolina:

• Little River (Broad River), a tributary of the Broad River
• Little River (Horry County, South Carolina), flowing directly into the Atlantic Ocean
  • Little River Inlet, the southern mouth of the above river
• Little River (McCormick County, South Carolina), a tributary of the Savannah River
• Little River (Oconee County, South Carolina), a tributary of the Keowee River
• Little River (Saluda River), a tributary of the Saluda River in Newberry and Laurens Counties

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