Combination of
SimethiconeGas reducer
Clinical data
Trade namesImodium Multi-Symptom Relief, Imodium Plus, Imodium Plus Comfort
  • AU: N
Routes of
By mouth
ATC code
Legal status
Legal status
  • UK: P and GSL
  • US: OTC

Loperamide/simethicone is combination medication marketed under the trade name Imodium Multi-Symptom Relief (formerly Imodium A-D Advanced) used to treat diarrhea and gas simultaneously. It is manufactured by the McNeil Consumer Healthcare Division of McNeil PPC, Inc. It contains loperamide and simethicone.

Loperamide is a μ-opioid receptor agonist that works in the intestines.[1] Although it is an opioid, it has no effects on the central nervous system. It reduces diarrhea by slowing the transit time of contents through the intestinal tract thereby allowing more water to be reabsorbed from the intestinal lumen.

Simethicone reduces gas by allowing smaller gas bubbles to coalesce into larger bubbles in the intestinal tract, making them easier to pass. Simethicone is not absorbed from the gastrointestinal tract so there are no systemic side effects.[2][3]


Anti-diarrheal medications should be avoided if diarrhea is secondary to an infection. Avoid using such products in the presence of fever, black stools, bloody stools, or stools containing mucus.[4]


  1. ^ Imodium, drugs.com
  2. ^ Simethicone, drugs.com
  3. ^ "Bloody Diarrhea". Retrieved 2013-02-11.
  4. ^ "Imodium Product Page". Archived from the original on 2012-06-10. Retrieved 2012-06-19.