Louie may refer to:

Arts and entertainment

• Louie (American TV series), comedy drama television series created by and starring comedian Louis C.K.
• Louie (French TV series), animated series about a young rabbit who draws pictures which come to life
• "Louie" (song), by Blood Raw
• Louie (album), a 2022 album by Kenny Beats

People

• Louie (given name)
• Louie (surname)

Fictional characters

• Louie, one of Donald Duck's nephews
• Louie De Palma, dispatcher in the television series Taxi
• King Louie, in the 1967 Disney animated film The Jungle Book (1967 film)
• Big Louie, a gangster-mafia boss in the 1987-1996 animated television series Teenage Mutant Ninja Turtles
• Louie, in the soap opera EastEnders
• Louie, a character in the strategy video game series Pikmin
• Louie, a comic strip created and drawn by Harry Hanan
• Buzz Saw Louie, a character in the VeggieTales video, The Toy That Saved Christmas

Mascots

• Louie the Bear, the St. Louis Blues mascot
• Louie the Laker, the Grand Valley State University mascot
• Louie the Lumberjack, the Northern Arizona University mascot

Other

• "Louie", a slang term for a Second lieutenant in the U.S. Army