He married in Madrid December 2, 1960, and divorced in 1983, Doña María del Carmen Sanchíz y Núñez-Robres (born 1942), 13th Marquise of La Casta, daughter of Hipólito Sánchiz y Quesada, 4th Count of Valdemar, of the Marquises of Vasto, and his wife, Doña María del Pilar Núñez-Robres y Rodríguez de Valcárcel of the Marquises of Montortal and Montenuevo, Counts of Pestagua, and had four children:
Donna Mónica Ruspoli dei Principi Ruspoli y Sanchíz, (born 1961), married in 1988 with Don Alonso Dezcallar y Mazarredo, Spanish ambassador, and had issue:
Doña Mónica Dezcallar y Ruspoli, Mazarredo y Sanchíz (August 9, 1990 –)
Doña Belén Dezcallar y Ruspoli, Mazarredo y Sanchíz (September 29, 1994 –)
Donna María de Belén Ruspoli dei Principi Ruspoli y Sanchíz, (born 1964), married in 1996 with Cesare Passi y Ferrero di Cambiano, Count Passi di Preposulo (born 1950) and had issue:
Don Alejandro Passi y Ruspoli, Ferrero di Cambiano y Sanchíz, dei Conti Passi di Preposulo (Madrid, January 6, 1998 –)
Donna María del Carmen Passi y Ruspoli, Ferrero di Cambiano y Sanchíz, dei Conti Passi di Preposulo (Madrid, November 17, 2003 –)
Don Luca Passi y Ruspoli, Ferrero di Cambiano y Sanchíz, dei Conti Passi di Preposulo (Madrid, November 20, 2006 –)
Don Santiago Ruspoli dei Principi Ruspoli y Sanchíz (1971 – 1996), unmarried and without issue.
Affonso, Domingos de Araújo; Valdez, Rui Dique Travassos (1938). Livro de Oiro da Nobreza. 3 volumes (in Portuguese). Vol. II. Lisbon.((cite book)): CS1 maint: location missing publisher (link)
Hobbs, Nicolas (2007). "Grandes de España" (in Spanish). Retrieved 15 October 2008.
Instituto de Salazar y Castro. Elenco de Grandezas y Titulos Nobiliarios Españoles (in Spanish). periodic publication.