M10, M-10 or M 10 may refer to:

Science and technology

Transportation

M10 (New York City bus), a New York City Bus route in Manhattan, US
M10 (New York City bus franchise), a New York City Bus route in Manhattan, US now named M21

M10 motorway (Great Britain), a former designation for a motorway in Hertfordshire, England
M-10 (Michigan highway), a road in Michigan
M10 (East London), a Metropolitan Route in East London, South Africa
M10 (Cape Town), a Metropolitan Route in Cape Town, South Africa
M10 (Johannesburg), a Metropolitan Route in Johannesburg, South Africa
M10 (Pretoria), a Metropolitan Route in Pretoria, South Africa
M10 (Durban), a Metropolitan Route in Durban, South Africa
M10 (Bloemfontein), a Metropolitan Route in Bloemfontein, South Africa
M10 (Port Elizabeth), a Metropolitan Route in Port Elizabeth, South Africa
M10 (Pietermaritzburg), a Metropolitan Route in Pietermaritzburg, South Africa
M10 motorway (Pakistan), a road located in Sindh province
M10 highway (Russia), a road connecting Saint Petersburg and Moscow
Highway M10 (Ukraine), a road in Ukraine
M10 road (Zambia), a road in Zambia
M10 road (Malawi), a road in Malawi

M10 tank destroyer, a US tank destroyer used in World War II
M10 Booker, selected by the US Army as the winner of its Mobile Protected Firepower program in June 2022
152-mm howitzer M1938 (M-10), a Soviet howitzer used in World War II
MAC-10, a machine pistol manufactured in the US
Remington Model 10, a US WWI-era pump-action shotgun
M10, a modern rifle based on the No. 4 action produced in Australia
M.10, a German World War I prototype base for one of the two Fokker B.II
M10, a scabbard for the M7 bayonet