Available structures
PDBOrtholog search: PDBe RCSB
AliasesMAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
External IDsOMIM: 601263 MGI: 1346867 HomoloGene: 48591 GeneCards: MAP2K2
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 4.09 – 4.12 MbChr 10: 80.94 – 80.97 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.[5] It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.[6]


The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.[7]


MAP2K2 has been shown to interact with MAPK3[8][9][10] and ARAF.[11]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126934Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035027Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem. 268 (15): 11435–9. doi:10.1016/S0021-9258(18)82142-1. PMID 8388392.
  6. ^ "MAP2K2 mitogen-activated protein kinase kinase 2 [Homo sapiens (human)] - Gene - NCBI". Retrieved 2015-10-16.
  7. ^ "Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2".
  8. ^ Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel T P, Kyriakis J M, Avruch J (Jan 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. 272 (5). UNITED STATES: 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895.
  9. ^ Butch ER, Guan K L (Feb 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. 271 (8). UNITED STATES: 4230–5. doi:10.1074/jbc.271.8.4230. ISSN 0021-9258. PMID 8626767.
  10. ^ Zheng CF, Guan K L (Nov 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. 268 (32). UNITED STATES: 23933–9. doi:10.1016/S0021-9258(20)80474-8. ISSN 0021-9258. PMID 8226933.
  11. ^ Yin XL, Chen She, Yan Jun, Hu Yun, Gu Jian X (Feb 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta. 1589 (1). Netherlands: 71–6. doi:10.1016/S0167-4889(01)00188-4. ISSN 0006-3002. PMID 11909642.

Further reading