AliasesMAP3K11, MEKK11, MLK-3, MLK3, PTK1, SPRK, mitogen-activated protein kinase kinase kinase 11
External IDsOMIM: 600050 MGI: 1346880 HomoloGene: 37618 GeneCards: MAP3K11
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 65.6 – 65.62 MbChr 19: 5.74 – 5.75 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.[5][6]


The protein encoded by this gene is called MLK3 and it is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates JNK and p38, and is found to be involved in the transcription activity of AP1 mediated by Rho family GTPases and CDC42.[7][8]


MAP3K11 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173327Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004054Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Smith CM, Ma NS, Nowak NJ, Shows TB, Gerhard DS (October 1997). "A 3-Mb Contig from D11S987 to MLK3, a Gene-Rich Region in 11q13". Genome Res. 7 (8): 835–42. doi:10.1101/gr.7.8.835. PMC 310665. PMID 9267807.
  6. ^ Ing YL, Leung IW, Heng HH, Tsui LC, Lassam NJ (June 1994). "MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain". Oncogene. 9 (6): 1745–50. PMID 8183572.
  7. ^ Kant S, Swat W, Zhang S, Zhang ZY, Neel BG, Flavell RA, Davis RJ (Oct 1, 2011). "TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway". Genes Dev. 25 (19): 2069–78. doi:10.1101/gad.17224711. PMC 3197205. PMID 21979919.
  8. ^ "Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11".
  9. ^ Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A (February 2003). "Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival". J. Biol. Chem. 278 (6): 3897–902. doi:10.1074/jbc.M211598200. PMID 12458207.
  10. ^ Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A (January 1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMC 1170366. PMID 9427749.
  11. ^ Böck BC, Vacratsis PO, Qamirani E, Gallo KA (May 2000). "Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". J. Biol. Chem. 275 (19): 14231–41. doi:10.1074/jbc.275.19.14231. PMID 10799501.
  12. ^ a b Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ (October 1999). "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245–54. doi:10.1128/mcb.19.10.7245. PMC 84717. PMID 10490659.
  13. ^ Figueroa C, Tarras S, Taylor J, Vojtek AB (November 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.

Further reading