MAP4K2
Identifiers
Aliases	MAP4K2, BL44, GCK, RAB8IP, mitogen-activated protein kinase kinase kinase kinase 2
External IDs	OMIM: 603166 MGI: 1346883 HomoloGene: 3370 GeneCards: MAP4K2
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 64,784,918 bp[1] End 64,803,241 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 6,391,165 bp[2] End 6,405,645 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen right lung monocyte lymph node upper lobe of left lung prefrontal cortex blood cingulate gyrus body of stomach amygdala Top expressed in thymus cerebellum spleen cerebellar cortex hypothalamus superior frontal gyrus bone marrow olfactory bulb islet of Langerhans lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity mitogen-activated protein kinase kinase kinase binding kinase activity protein serine/threonine kinase activity protein binding ATP binding MAP kinase kinase kinase kinase activity Cellular component Golgi apparatus membrane Golgi membrane plasma membrane basolateral plasma membrane cytoplasm Biological process intracellular signal transduction vesicle targeting phosphorylation immune system process positive regulation of JNK cascade protein phosphorylation JNK cascade immune response innate immune response regulation of mitotic cell cycle regulation of apoptotic process signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5871 26412 Ensembl ENSG00000168067 ENSMUSG00000024948 UniProt Q12851 Q61161 RefSeq (mRNA) NM_001307990 NM_004579 NM_001291787 NM_009006 RefSeq (protein) NP_001294919 NP_004570 NP_001278716 NP_033032 Location (UCSC) Chr 11: 64.78 – 64.8 Mb Chr 19: 6.39 – 6.41 Mb PubMed search [3] [4]
Wikidata
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Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene.^[5][6]

Function

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1.^[6] A recent study showed that MAP4K2 is a direct kinase of LATS1/2 and thus regulates the Hippo pathway effectors YAP and TAZ.^[7][8]

Interactions

MAP4K2 has been shown to interact with RAB8A^[9] and TRAF2.^[10]