MAPK11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GC8, 3GC9, 3GP0
Identifiers
Aliases	MAPK11, P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta, mitogen-activated protein kinase 11
External IDs	OMIM: 602898 MGI: 1338024 HomoloGene: 55684 GeneCards: MAPK11
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.33 Start 50,263,713 bp[1] End 50,270,767 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E3 Start 89,026,689 bp[2] End 89,033,831 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 middle temporal gyrus cingulate gyrus caudate nucleus Brodmann area 23 putamen nucleus accumbens anterior pituitary amygdala ganglionic eminence Top expressed in visual cortex superior frontal gyrus superior cervical ganglion ganglionic eminence primary motor cortex cerebellar cortex blood facial motor nucleus prefrontal cortex conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity MAP kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytosol nucleoplasm nucleus cytoplasm Biological process regulation of transcription, DNA-templated regulation of cardiac muscle cell proliferation positive regulation of erythrocyte differentiation phosphorylation positive regulation of muscle cell differentiation transcription, DNA-templated protein phosphorylation positive regulation of gene expression negative regulation of cardiac muscle cell proliferation regulation of signal transduction by p53 class mediator stress-activated MAPK cascade cellular response to interleukin-1 regulation of gene expression intracellular signal transduction cellular response to organic substance Ras protein signal transduction vascular endothelial growth factor receptor signaling pathway regulation of DNA-binding transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5600 19094 Ensembl ENSG00000185386 ENSMUSG00000053137 UniProt Q15759 Q9WUI1 RefSeq (mRNA) NM_002751 NM_011161 RefSeq (protein) NP_002742 NP_035291 Location (UCSC) Chr 22: 50.26 – 50.27 Mb Chr 15: 89.03 – 89.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene.^[5][6]

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.^[6]

Interactions

MAPK11 has been shown to interact with HDAC3^[7] and Promyelocytic leukemia protein.^[8]