MARCHF2
Identifiers
AliasesMARCHF2, MARCH-II, RNF172, HSPC240, membrane associated ring-CH-type finger 2, MARCH2
External IDsOMIM: 613332 MGI: 1925915 HomoloGene: 9539 GeneCards: MARCHF2
Orthologs
SpeciesHumanMouse
Entrez

51257

224703

Ensembl

ENSG00000099785

ENSMUSG00000079557

UniProt

Q9P0N8

Q99M02

RefSeq (mRNA)

NM_001252480
NM_145486

RefSeq (protein)

NP_001239409
NP_663461

Location (UCSC)Chr 19: 8.41 – 8.44 MbChr 17: 33.9 – 33.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene.[5][6][7] It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins.[8] MARCH2 has been shown to negatively regulate NF-κB essential modulator function upon viral and bacterial infections.[9]

Gene name error in Excel

Main article: Microsoft Excel § Conversion_problems

Like the other MARCH and septin genes, care must be exercised when analyzing genetic data containing the MARCH2 gene in Microsoft Excel.[10] This is due to Excel's autocorrect feature treating the MARCH gene as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.[11] The issue can be prevented by using an alias name such as MARCHF2, prepending with an apostrophe ('), or preformatting the cell as text.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099785 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079557 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. ^ Bartee E, Mansouri M, Hovey Nerenberg BT, Gouveia K, Früh K (February 2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". Journal of Virology. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
  7. ^ "Entrez Gene: MARCH2 membrane-associated ring finger (C3HC4) 2".
  8. ^ Zhang Y, Lu J, Liu X (May 2018). "MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation". Virology. 518: 293–300. doi:10.1016/j.virol.2018.02.003. PMID 29573664.
  9. ^ Chathuranga K, Kim TH, Lee H, Park JS, Kim JH, Chathuranga WA, Ekanayaka P, Choi YJ, Lee CH, Kim CJ, Jung JU, Lee JS (2020). "Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2". The EMBO Journal. 39 (21): e105139. doi:10.15252/embj.2020105139. PMC 7604578. PMID 32935379. S2CID 221745904.
  10. ^ Zeeberg BR, Riss J, Kane DW, Bussey KJ, Uchio E, Linehan WM, et al. (June 2004). "Mistaken identifiers: gene name errors can be introduced inadvertently when using Excel in bioinformatics". BMC Bioinformatics. 5 (1): 80. doi:10.1186/1471-2105-5-80. PMC 459209. PMID 15214961.
  11. ^ Ziemann M, Eren Y, El-Osta A (August 2016). "Gene name errors are widespread in the scientific literature". Genome Biology. 17 (1): 177. doi:10.1186/s13059-016-1044-7. PMC 4994289. PMID 27552985.

Further reading


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