MIP
Identifiers
AliasesMIP, AQP0, CTRCT15, LIM1, MIP26, MP26, major intrinsic protein of lens fiber
External IDsOMIM: 154050 MGI: 96990 HomoloGene: 40627 GeneCards: MIP
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012064

NM_008600

RefSeq (protein)

NP_036196

NP_032626

Location (UCSC)Chr 12: 56.45 – 56.47 MbChr 10: 128.23 – 128.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lens fiber major intrinsic protein is a protein that in humans is encoded by the MIP gene.[5][6][7]

Function

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135517 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025389 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pisano MM, Chepelinsky AB (Mar 1992). "Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens". Genomics. 11 (4): 981–90. doi:10.1016/0888-7543(91)90023-8. PMID 1840563.
  6. ^ Mulders SM, Preston GM, Deen PM, Guggino WB, van Os CH, Agre P (May 1995). "Water channel properties of major intrinsic protein of lens". J Biol Chem. 270 (15): 9010–16. doi:10.1074/jbc.270.15.9010. hdl:2066/21519. PMID 7536742.
  7. ^ a b "Entrez Gene: MIP major intrinsic protein of lens fiber".

Further reading