MIR223
Identifiers
Aliases	MIR223, MIRN223, miRNA223, mir-223, microRNA 223
External IDs	OMIM: 300694 GeneCards: MIR223
Gene location (Human) Chr. X chromosome (human)[1] Band Xq12 Start 66,018,870 bp[1] End 66,018,979 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood left ventricle sural nerve kidney gastrocnemius muscle ascending aorta adrenal gland minor salivary gland caudate nucleus pituitary gland n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 407008 n/a Ensembl ENSG00000284567 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr X: 66.02 – 66.02 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

MicroRNA 223 is a protein that in humans is encoded by the MIR223 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].