MIR503
Identifiers
Aliases	MIR503, MIRN503, hsa-mir-503, mir-503, microRNA 503
External IDs	OMIM: 300865 GeneCards: MIR503
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.3 Start 134,546,328 bp[1] End 134,546,398 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta endometrium muscle of leg kidney blood gastrocnemius muscle right adrenal gland heart left ventricle body of stomach n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 574506 n/a Ensembl ENSG00000208005 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr X: 134.55 – 134.55 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

MicroRNA 503 is a non-coding RNA molecule that in humans is encoded by the MIR503 gene. ^[3]

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.