Preferred IUPAC name
Other names
3D model (JSmol)
  • InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
  • InChI=1/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
  • Clc1nc(cnc1)N2CCNCC2
Molar mass 198.65 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

MK-212 (CPP or 6-chloro-2-(1-piperazinyl)pyrazine)[1] is a serotonin agonist.[2] It promotes the secretion of serum prolactin and cortisol in humans.[3]


In an experiment performed by Clineschidt and colleagues, they dosed mice with varying concentrations of MK-212, and observed its effects.[4] The result correlated very well to binding of indolealkylamine receptors, such as the serotonin and tryptamine receptors, which shows four characteristics. Namely, increased frequency of muscle twitching, increased twitching of the head,[5] "an increase in the strength of the crossed extensor reflex in the acutely spinalized rat", and the cause of complex motor syndrome.[4]

See also


  1. ^ Clineschidmt BV (1979). "MK-212: a serotonin-like agonist in the CNS". General Pharmacology. 10 (4): 287–90. doi:10.1016/0306-3623(79)90054-5. PMID 488663.
  2. ^ Bastani B, Nash JF, Meltzer HY (September 1990). "Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder". Archives of General Psychiatry. 47 (9): 833–9. doi:10.1001/archpsyc.1990.01810210041006. PMID 2203327.
  3. ^ Lowy MT, Meltzer HY (April 1988). "Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist". Biological Psychiatry. 23 (8): 818–28. doi:10.1016/0006-3223(88)90070-4. PMID 3365458. S2CID 32736259.
  4. ^ a b Clineschmidt BV, Mcguffin JC, Pflueger AB (July 1977). "Central serotonin-like activity of 6-chloro-2-[1-piperazinyl]-pyrazine (CPP; MK-212)". European Journal of Pharmacology. 44 (1): 65–74. doi:10.1016/0014-2999(77)90117-0. PMID 885160.
  5. ^ Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, et al. (September 1999). "Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells". British Journal of Pharmacology. 128 (1): 13–20. doi:10.1038/sj.bjp.0702751. PMC 1571597. PMID 10498829.