MLX
Identifiers
Aliases	MLX, MAD7, MXD7, TCFL4, bHLHd13, MAX dimerization protein, TF4, MAX dimerization protein MLX
External IDs	OMIM: 602976 MGI: 108398 HomoloGene: 7969 GeneCards: MLX
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,567,072 bp[1] End 42,573,239 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 100,978,103 bp[2] End 100,983,033 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte parotid gland duodenum jejunal mucosa rectum left ventricle gastrocnemius muscle right ventricle monocyte Top expressed in duodenum jejunum proximal tubule colon yolk sac left colon thymus stomach ileum superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding protein homodimerization activity DNA-binding transcription repressor activity, RNA polymerase II-specific protein dimerization activity protein heterodimerization activity DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytoplasm nucleoplasm cytosol nuclear membrane Biological process negative regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6945 21428 Ensembl ENSG00000108788 ENSMUSG00000017801 UniProt Q9UH92 O08609 RefSeq (mRNA) NM_198205 NM_170607 NM_198204 NM_013383 NM_170608 NM_001159384 NM_001159385 NM_011550 RefSeq (protein) NP_733752 NP_937847 NP_937848 NP_001152856 NP_001152857 NP_035680 Location (UCSC) Chr 17: 42.57 – 42.57 Mb Chr 11: 100.98 – 100.98 Mb PubMed search [3] [4]
Wikidata
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Max-like protein X is a protein that in humans is encoded by the MLX gene.^[5][6]

Function

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.^[6]

Interactions

MLX (gene) has been shown to interact with MNT,^[7][8] MXD1^[7][8] and MLXIPL.^[7]

MLX must dimerize with MondoA^[9] or with MLXIPL (carbohydrate-responsive element-binding protein) to regulate target genes.^[10]