MMP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Q3A, 3V96, 4ILW
Identifiers
Aliases	MMP10, SL-2, STMY2, matrix metallopeptidase 10
External IDs	OMIM: 185260 MGI: 97007 HomoloGene: 20546 GeneCards: MMP10
EC number	3.4.24.22
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.2 Start 102,770,502 bp[1] End 102,780,628 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 7,502,353 bp[2] End 7,510,241 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva islet of Langerhans stromal cell of endometrium pancreatic epithelial cell Achilles tendon appendix amniotic fluid periodontal fiber bronchial epithelial cell trachea Top expressed in duodenum jejunum Paneth cell ileum colon ovary muscle of leg uterus integument integument More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding serine-type endopeptidase activity Cellular component extracellular region extracellular space extracellular matrix Biological process collagen catabolic process extracellular matrix disassembly regulation of cell migration proteolysis response to hypoxia extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4319 17384 Ensembl ENSG00000166670 ENSMUSG00000047562 UniProt P09238 O55123 RefSeq (mRNA) NM_002425 NM_019471 RefSeq (protein) NP_002416 NP_062344 Location (UCSC) Chr 11: 102.77 – 102.78 Mb Chr 9: 7.5 – 7.51 Mb PubMed search [3] [4]
Wikidata
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Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.^[5][6]

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.^[7]

Clinical significance

MMP10 has been linked to cancer stem cell vitality and metastasis.^[8]

MMP10 is a potential prognostic biomarker for oral cancer.^{[9][unreliable medical source]}