MNDA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2DBG
Identifiers
Aliases	MNDA, PYHIN3, myeloid cell nuclear differentiation antigen
External IDs	OMIM: 159553 HomoloGene: 74438 GeneCards: MNDA
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.1 Start 158,831,351 bp[1] End 158,849,506 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte spongy bone blood bone marrow periodontal fiber germinal epithelium bone marrow cells spleen palpebral conjunctiva right lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding double-stranded DNA binding Cellular component cytoplasm extracellular exosome nucleus extracellular region nucleoplasm nucleolus azurophil granule lumen ficolin-1-rich granule lumen Biological process B cell receptor signaling pathway cellular defense response regulation of transcription, DNA-templated negative regulation of B cell proliferation transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of apoptotic process neutrophil degranulation activation of innate immune response cellular response to interferon-beta positive regulation of interleukin-1 beta production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4332 n/a Ensembl ENSG00000163563 n/a UniProt P41218 n/a RefSeq (mRNA) NM_002432 n/a RefSeq (protein) NP_002423 n/a Location (UCSC) Chr 1: 158.83 – 158.85 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.^[3][4][5]

Function

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.^[5]