MRPL11
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL11, L11MT, MRP-L11, CGI-113, mitochondrial ribosomal protein L11
External IDsOMIM: 611826 MGI: 2137215 HomoloGene: 6768 GeneCards: MRPL11
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016050
NM_170738
NM_170739

NM_025553

RefSeq (protein)

NP_057134
NP_733934
NP_733935

NP_079829

Location (UCSC)Chr 11: 66.44 – 66.47 MbChr 19: 4.96 – 4.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174547 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024902 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPL11 mitochondrial ribosomal protein L11".

Further reading