MRPL23
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL23, L23MRP, RPL23, RPL23L, mitochondrial ribosomal protein L23
External IDsOMIM: 600789 MGI: 1196612 HomoloGene: 7922 GeneCards: MRPL23
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021134

NM_011288

RefSeq (protein)

NP_066957

NP_035418

Location (UCSC)Chr 11: 1.95 – 1.98 MbChr 7: 142.53 – 142.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L23, mitochondrial is a protein that in humans is encoded by the MRPL23 gene.[5][6]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.[6]

References

  1. ^ a b c ENSG00000288141 GRCh38: Ensembl release 89: ENSG00000214026, ENSG00000288141 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037772 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tsang P, Gilles F, Yuan L, Kuo YH, Lupu F, Samara G, Moosikasuwan J, Goye A, Zelenetz AD, Selleri L (Feb 1996). "A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues". Hum Mol Genet. 4 (9): 1499–507. doi:10.1093/hmg/4.9.1499. PMID 8541832.
  6. ^ a b "Entrez Gene: MRPL23 mitochondrial ribosomal protein L23".

Further reading