MRPS7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS7, MRP-S, MRP-S7, RP-S7, RPMS7, S7mt, bMRP27a, mitochondrial ribosomal protein S7, COXPD34
External IDs	OMIM: 611974 MGI: 1354367 HomoloGene: 9321 GeneCards: MRPS7
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 75,261,674 bp[1] End 75,266,376 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,494,751 bp[2] End 115,498,862 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle left ventricle right adrenal gland left adrenal gland rectum body of stomach triceps brachii muscle right lobe of liver skeletal muscle tissue body of tongue Top expressed in right ventricle interventricular septum proximal tubule plantaris muscle left lobe of liver masseter muscle temporal muscle extensor digitorum longus muscle sternocleidomastoid muscle triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding mRNA binding structural constituent of ribosome rRNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination mitochondrial translation ribosomal small subunit assembly protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51081 50529 Ensembl ENSG00000125445 ENSMUSG00000046756 UniProt Q9Y2R9 Q80X85 RefSeq (mRNA) NM_015971 NM_025305 RefSeq (protein) NP_057055 NP_079581 Location (UCSC) Chr 17: 75.26 – 75.27 Mb Chr 11: 115.49 – 115.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.^[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p.^[5]