IRAG1
Identifiers
AliasesIRAG1, IRAG, JAW1L, murine retrovirus integration site 1 homolog, MRVI1, inositol 1,4,5-triphosphate receptor associated 1
External IDsOMIM: 604673 MGI: 1338023 HomoloGene: 4425 GeneCards: IRAG1
Orthologs
SpeciesHumanMouse
Entrez

10335

17540

Ensembl

ENSG00000072952

ENSMUSG00000005611

UniProt

Q9Y6F6

Q9WUX5

RefSeq (mRNA)

NM_010826
NM_194464

RefSeq (protein)

NP_034956
NP_919446

Location (UCSC)Chr 11: 10.57 – 10.69 MbChr 7: 110.47 – 110.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein MRVI1 is a protein that in humans is encoded by the MRVI1 gene.[5][6]

Function

This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcripts have been found for this gene, however, the full-length nature of some variants has not been determined. Of the two characterized variants which encode different isoforms, one initiates translation at a non-AUG start site.[6]

Interactions

MRVI1 has been shown to interact with ITPR1[7] and PRKG1.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072952 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005611 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shaughnessy JD, Largaespada DA, Tian E, Fletcher CF, Cho BC, Vyas P, Jenkins NA, Copeland NG (June 1999). "Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1". Oncogene. 18 (12): 2069–84. doi:10.1038/sj.onc.1202419. PMID 10321731.
  6. ^ a b "Entrez Gene: MRVI1 murine retrovirus integration site 1 homolog".
  7. ^ a b Schlossmann J, Ammendola A, Ashman K, Zong X, Huber A, Neubauer G, Wang GX, Allescher HD, Korth M, Wilm M, Hofmann F, Ruth P (March 2000). "Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta". Nature. 404 (6774): 197–201. doi:10.1038/35004606. PMID 10724174. S2CID 205004996.
  8. ^ Ammendola A, Geiselhöringer A, Hofmann F, Schlossmann J (June 2001). "Molecular determinants of the interaction between the inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate (IRAG) and cGMP kinase Ibeta". J. Biol. Chem. 276 (26): 24153–9. doi:10.1074/jbc.M101530200. PMID 11309393.

Further reading

External links

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