MT-TA
Identifiers
AliasesMT-TA, TRNA
External IDsOMIM: 590000 MGI: 102491 GeneCards: MT-TA
Orthologs
SpeciesHumanMouse
Entrez

4553

17726

Ensembl

ENSG00000210127

ENSMUSG00000064347

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search[1][2]
Wikidata
View/Edit HumanView/Edit Mouse

Mitochondrially encoded tRNA alanine also known as MT-TA is a transfer RNA, which in humans is encoded by the mitochondrial MT-TA gene.[3]

MT-TA is a small 69 nucleotide RNA (human mitochondrial map position 5587-5655) that transfers the amino acid alanine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.

It has been reported that the 5650G-A mutation on MT-TA may cause muscular dystrophy.[4]

References

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Anderson S, Bankier AT, Barrell BG, de Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, Schreier PH, Smith AJ, Staden R, Young IG (April 1981). "Sequence and organization of the human mitochondrial genome". Nature. 290 (5806): 457–65. Bibcode:1981Natur.290..457A. doi:10.1038/290457a0. PMID 7219534. S2CID 4355527.
  4. ^ Horvath, R (2003). "A tRNAAla mutation causing mitochondrial myopathy clinically resembling myotonic dystrophy". Journal of Medical Genetics. 40 (10): 752–757. doi:10.1136/jmg.40.10.752. ISSN 1468-6244. PMC 1735288. PMID 14569122.


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