MX1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMX1, IFI-78K, IFI78, MX, MxA, MX dynamin like GTPase 1, lncMX1-215
External IDsOMIM: 147150 HomoloGene: 1844 GeneCards: MX1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001144925
NM_001178046
NM_001282920
NM_002462

n/a

RefSeq (protein)

NP_001138397
NP_001171517
NP_001269849
NP_002453

n/a

Location (UCSC)Chr 21: 41.42 – 41.47 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.[3][4]

In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major determinant for influenza viruses of animal origin.[5] The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.[4]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157601Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Haller O, Staeheli P, Kochs G (Jul 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie. 89 (6–7): 812–8. doi:10.1016/j.biochi.2007.04.015. PMID 17570575.
  4. ^ a b "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)".
  5. ^ Ciminski, Kevin; Chase, Geoffrey; Beer, Martin; Schwemmle, Martin (2021). "Influenza A Viruses: Understanding Human Host Determinants". Trends in Molecular Medicine. 27 (2): 104–112. doi:10.1016/j.molmed.2020.09.014. PMID 33097424. S2CID 225058479.

Further reading