MXI1
Identifiers
Aliases	MXI1, MAD2, MXD2, MXI, bHLHc11, MAX interactor 1, dimerization protein
External IDs	OMIM: 600020 MGI: 97245 HomoloGene: 4351 GeneCards: MXI1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 110,207,605 bp[1] End 110,287,365 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D2|19 47.53 cM Start 53,298,949 bp[2] End 53,364,241 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in optic nerve Achilles tendon corpus callosum inferior ganglion of vagus nerve spongy bone parotid gland middle frontal gyrus subthalamic nucleus external globus pallidus postcentral gyrus Top expressed in blood cerebellar vermis molar median eminence olfactory epithelium pontine nuclei medial geniculate nucleus seminal vesicula inferior colliculus cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding protein dimerization activity transcription corepressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleolus nucleus cytosol RNA polymerase II transcription regulator complex Biological process cytoplasmic sequestering of transcription factor regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of cell population proliferation negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4601 17859 Ensembl ENSG00000119950 ENSMUSG00000025025 UniProt P50539 P50540 RefSeq (mRNA) NM_130439 NM_001008541 NM_005962 NM_001008542 NM_001008543 NM_010847 NM_001360345 NM_001360346 NM_001360347 NM_001360348 RefSeq (protein) NP_001008541 NP_005953 NP_569157 NP_001008542 NP_001008543 NP_034977 NP_001347274 NP_001347275 NP_001347276 NP_001347277 Location (UCSC) Chr 10: 110.21 – 110.29 Mb Chr 19: 53.3 – 53.36 Mb PubMed search [3] [4]
Wikidata
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MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.^[5][6]

Function

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.^[6]

Interactions

MXI1 has been shown to interact with SMC3^[7] and MAX.^{[7][8][9][10][11]}