MYLK3
Identifiers
Aliases	MYLK3, MLCK, MLCK2, caMLCK, myosin light chain kinase 3
External IDs	OMIM: 612147 MGI: 2443063 HomoloGene: 35278 GeneCards: MYLK3
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q11.2 Start 46,702,282 bp[1] End 46,790,407 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 86,050,932 bp[2] End 86,112,974 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle body of tongue thoracic diaphragm triceps brachii muscle vena cava vastus lateralis muscle deltoid muscle glomerulus metanephric glomerulus tibialis anterior muscle Top expressed in myocardium of ventricle atrium interventricular septum atrioventricular valve esophagus endocardial cushion left ventricle bone marrow semi-lunar valve aortic valve More reference expression data BioGPS n/a
Gene ontology Molecular function calmodulin-dependent protein kinase activity kinase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity transferase activity ATP binding myosin light chain kinase activity Cellular component cytoplasm actin cytoskeleton cytosol intracellular anatomical structure Biological process protein phosphorylation positive regulation of sarcomere organization regulation of vascular permeability involved in acute inflammatory response sarcomere organization cellular response to interleukin-1 phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction sarcomerogenesis cardiac myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91807 213435 Ensembl ENSG00000140795 ENSMUSG00000031698 UniProt Q32MK0 Q3UIZ8 RefSeq (mRNA) NM_001308301 NM_182493 NM_001297612 NM_175441 RefSeq (protein) NP_001295230 NP_872299 NP_001284541 NP_780650 Location (UCSC) Chr 16: 46.7 – 46.79 Mb Chr 8: 86.05 – 86.11 Mb PubMed search [3] [4]
Wikidata
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Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.^[5][6]

Function

Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.^[7]