MacDonough is an Irish surname, it may refer to:

Surname

• Elizabeth MacDonough, the current Parliamentarian of the United States Senate
• George MacDonough or George Macdonogh GBE KCB KCMG (1865–1942), British Army general officer
• Glen MacDonough (1870–1924), US American writer, lyricist and librettist
• Harry Macdonough (1871–1931), Canadian singer and recording executive
• James MacDonough (born 1970) American professional bass guitarist
• Thomas Macdonough (1783–1825), early-19th-century American naval officer noted for his roles in the first Barbary War and the War of 1812

Given name

• Macdonough Craven, (1858–1919), American naval officer, engineer, and politician
• Tunis Augustus Macdonough Craven (1813–1864), officer in the United States Navy

Places

• MacDonough, Delaware, a small unincorporated community in New Castle County, Delaware, United States
• MacDonough Island, a large island in the Possession Sound portion of Puget Sound, located in Island County, Washington
• Commodore Thomas MacDonough Highway, State Route 314 (New York–Vermont) (NY 314) and Vermont Route 314 (VT 314)
• Comdr. Thomas MacDonough House, a historic home located near Odessa, New Castle County, Delaware

Ships

• USS Macdonough (DD-331), Clemson-class destroyer built for the United States Navy during World War I
• USS Macdonough (DD-351), Farragut-class destroyer in the United States Navy during World War II
• USS Macdonough (DD-9), Lawrence-class destroyer, which was a sub-class of Bainbridge-class destroyer, in the United States Navy
• USS Macdonough (DDG-39), Farragut class guided missile destroyer in the United States Navy