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The Maltese Second and Third Division Knock-Out was a football competition contested by teams playing in the Maltese Second and Third Division. The format consisted of the teams being drawn into eight groups, with the winners of each group progressing to the knockout phase of the competition.

Winners

Key to list of winners
† Match decided by a penalty shoot-out after extra time
Season Winners Score Runners–up
2000–01 Żebbuġ Rangers 4–1 Vittoriosa Stars
2001–02 Dingli Swallows 2–0 Żebbuġ Rangers
2002–03 Tarxien Rainbows 4–1 Sirens
2003–04 Mellieħa 2–1 Żebbuġ Rangers
2004–05 Qormi 1–0 Mellieħa
2005–06 Qormi 1–0† Gżira United
2006–07 Balzan Youths 2–0 Birżebbuġa St. Peter's
2007–08 Melita 5–1 Balzan Youths
2008–09 Melita 3–0 St. Venera Lightnings
2009–10 Żejtun Corinthians 2–1 Għargħur
2010–11 Żejtun Corinthians 2–0 Rabat Ajax
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