American geneticist
Martin Edward Kreitman is an American geneticist at the University of Chicago ,[3] [4] [5] most well known for the McDonald–Kreitman test that is used to infer the amount of adaptive evolution in population genetic studies.
Education
Kreitman graduated from Stony Brook University with a Bachelor of Science degree Biology in 1975, and from the University of Florida with a Master of Science degree in Zoology , in 1977. He went on to study at Harvard University , graduating with a Ph.D. in Population Genetics , specifically Nucleotide Sequence Variation of Alcohol dehydrogenase in Drosophila melanogaster [6] in 1983.[7]
Recent publications
Ludwig, M. Z.; Manu; Kittler, R.; White, K. P.; Kreitman, M. (2011). Malik, Harmit S (ed.). "Consequences of Eukaryotic Enhancer Architecture for Gene Expression Dynamics, Development, and Fitness" . PLOS Genetics . 7 (11): e1002364. doi :10.1371/journal.pgen.1002364 . PMC 3213169 . PMID 22102826 .
He, B. Z.; Holloway, A. K.; Maerkl, S. J.; Kreitman, M. (2011). Petrov, Dmitri A (ed.). "Does Positive Selection Drive Transcription Factor Binding Site Turnover? A Test with Drosophila Cis-Regulatory Modules" . PLOS Genetics . 7 (4): e1002053. doi :10.1371/journal.pgen.1002053 . PMC 3084208 . PMID 21572512 .
Lott, S. E.; Ludwig, M. Z.; Kreitman, M. (2011). "Evolution and Inheritance of Early Embryonic Patterning in Drosophila Simulans and D. Sechellia" . Evolution . 65 (5): 1388–1399. doi :10.1111/j.1558-5646.2010.01206.x . PMC 3083464 . PMID 21121913 .
Bakker, E. G.; Traw, M. B.; Toomajian, C.; Kreitman, M.; Bergelson, J. (2008). "Low Levels of Polymorphism in Genes That Control the Activation of Defense Response in Arabidopsis thaliana" . Genetics . 178 (4): 2031–2043. doi :10.1534/genetics.107.083279 . PMC 2323794 . PMID 18245336 .
Araki, H.; Innan, H.; Kreitman, M.; Bergelson, J. (2007). "Molecular Evolution of Pathogenicity-Island Genes in Pseudomonas viridiflava" . Genetics . 177 (2): 1031–1041. doi :10.1534/genetics.107.077925 . PMC 2034611 . PMID 17720907 .
Lott, S. E.; Kreitman, M.; Palsson, A.; Alekseeva, E.; Ludwig, M. Z. (2007). "Canalization of segmentation and its evolution in Drosophila" . Proceedings of the National Academy of Sciences . 104 (26): 10926–10931. Bibcode :2007PNAS..10410926L . doi :10.1073/pnas.0701359104 . PMC 1891814 . PMID 17569783 .
Bakker, E. G. (2006). "A Genome-Wide Survey of R Gene Polymorphisms in Arabidopsis" . The Plant Cell Online . 18 (8): 1803–1818. doi :10.1105/tpc.106.042614 . PMC 1533970 . PMID 16798885 .
Bakker, E. G.; Stahl, E. A.; Toomajian, C.; Nordborg, M.; Kreitman, M.; Bergelson, J. (2006). "Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range". Molecular Ecology . 15 (5): 1405–1418. Bibcode :2006MolEc..15.1405B . doi :10.1111/j.1365-294X.2006.02884.x . PMID 16626462 . S2CID 2070755 .
Araki, H. (2006). "Presence/absence polymorphism for alternative pathogenicity islands in Pseudomonas viridiflava, a pathogen of Arabidopsis" . Proceedings of the National Academy of Sciences . 103 (15): 5887–5892. Bibcode :2006PNAS..103.5887A . doi :10.1073/pnas.0601431103 . PMC 1458668 . PMID 16581904 .
Nordborg, M.; Hu, T. T.; Ishino, Y.; Jhaveri, J.; Toomajian, C.; Zheng, H.; Bakker, E.; Calabrese, P.; Gladstone, J.; Goyal, R.; Jakobsson, M.; Kim, S.; Morozov, Y.; Padhukasahasram, B.; Plagnol, V.; Rosenberg, N. A.; Shah, C.; Wall, J. D.; Wang, J.; Zhao, K.; Kalbfleisch, T.; Schulz, V.; Kreitman, M.; Bergelson, J. (2005). "The Pattern of Polymorphism in Arabidopsis thaliana" . PLOS Biology . 3 (7): e196. doi :10.1371/journal.pbio.0030196 . PMC 1135296 . PMID 15907155 .
Ludwig, M. Z.; Palsson, A.; Alekseeva, E.; Bergman, C. M.; Nathan, J.; Kreitman, M. (2005). "Functional Evolution of a cis-Regulatory Module" . PLOS Biology . 3 (4): e93. doi :10.1371/journal.pbio.0030093 . PMC 1064851 . PMID 15757364 .
Kreitman, M.; Di Rienzo, A. (2004). "Balancing claims for balancing selection". Trends in Genetics . 20 (7): 300–304. doi :10.1016/j.tig.2004.05.002 . PMID 15219394 .
Goss, E. M.; Kreitman, M.; Bergelson, J. (2004). "Genetic Diversity, Recombination and Cryptic Clades in Pseudomonas viridiflava Infecting Natural Populations of Arabidopsis thaliana" . Genetics . 169 (1): 21–35. doi :10.1534/genetics.104.031351 . PMC 1448860 . PMID 15489535 .
Mauricio, R.; Stahl, E. A.; Korves, T.; Tian, D.; Kreitman, M.; Bergelson, J. (2003). "Natural selection for polymorphism in the disease resistance gene Rps2 of Arabidopsis thaliana" . Genetics . 163 (2): 735–746. doi :10.1093/genetics/163.2.735 . PMC 1462445 . PMID 12618410 .
Tian, D.; Traw, M. B.; Chen, J. Q.; Kreitman, M.; Bergelson, J. (2003). "Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana". Nature . 423 (6935): 74–77. Bibcode :2003Natur.423...74T . doi :10.1038/nature01588 . PMID 12721627 . S2CID 4394776 .
Toomajian, C.; Ajioka, R. S.; Jorde, L. B.; Kushner, J. P.; Kreitman, M. (2003). "A method for detecting recent selection in the human genome from allele age estimates" . Genetics . 165 (1): 287–297. doi :10.1093/genetics/165.1.287 . PMC 1462736 . PMID 14504236 .
Tian, D. (2002). "Signature of balancing selection in Arabidopsis" . Proceedings of the National Academy of Sciences . 99 (17): 11525–11530. Bibcode :2002PNAS...9911525T . doi :10.1073/pnas.172203599 . PMC 123289 . PMID 12172007 .
Toomajian, C.; Kreitman, M. (2002). "Sequence variation and haplotype structure at the human HFE locus" . Genetics . 161 (4): 1609–1623. doi :10.1093/genetics/161.4.1609 . PMC 1462210 . PMID 12196404 .
Jakob, K.; Goss, E. M.; Araki, H.; Van, T.; Kreitman, M.; Bergelson, J. (2002). "Pseudomonas viridiflavaandP. Syringae—Natural Pathogens ofArabidopsis thaliana". Molecular Plant-Microbe Interactions . 15 (12): 1195–1203. doi :10.1094/MPMI.2002.15.12.1195 . PMID 12481991 .
Comeron, J. M.; Kreitman, M. (2002). "Population, evolutionary and genomic consequences of interference selection" . Genetics . 161 (1): 389–410. doi :10.1093/genetics/161.1.389 . PMC 1462104 . PMID 12019253 .
Nordborg, M.; Borevitz, J. O.; Bergelson, J.; Berry, C. C.; Chory, J.; Hagenblad, J.; Kreitman, M.; Maloof, J. N.; Noyes, T.; Oefner, P. J.; Stahl, E. A.; Weigel, D. (2002). "The extent of linkage disequilibrium in Arabidopsis thaliana". Nature Genetics . 30 (2): 190–193. doi :10.1038/ng813 . PMID 11780140 . S2CID 29420110 .
Bergman, C. M.; Kreitman, M. (2001). "Analysis of Conserved Noncoding DNA in Drosophila Reveals Similar Constraints in Intergenic and Intronic Sequences" . Genome Research . 11 (8): 1335–1345. doi :10.1101/gr.178701 . PMID 11483574 .
Bergelson, J.; Kreitman, M.; Stahl, E. A.; Tian, D. (2001). "Evolutionary Dynamics of Plant R-Genes". Science . 292 (5525): 2281–2285. doi :10.1126/science.1061337 . PMID 11423651 . S2CID 21638017 .
Comeron, J. M.; Kreitman, M. (2000). "The correlation between intron length and recombination in drosophila. Dynamic equilibrium between mutational and selective forces" . Genetics . 156 (3): 1175–1190. doi :10.1093/genetics/156.3.1175 . PMC 1461334 . PMID 11063693 .
Ludwig, M. Z.; Bergman, C.; Patel, N. H.; Kreitman, M. (2000). "Evidence for stabilizing selection in a eukaryotic enhancer element". Nature . 403 (6769): 564–567. Bibcode :2000Natur.403..564L . doi :10.1038/35000615 . PMID 10676967 . S2CID 4425113 .
Bergelson, J.; Stahl, E. A.; Dwyer, G.; Mauricio, R.; Kreitman, M. (1999). "Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis". Nature . 400 (6745): 667–671. Bibcode :1999Natur.400..667S . doi :10.1038/23260 . PMID 10458161 . S2CID 4380447 .
Comeron, J. M.; Kreitman, M.; Aguadé, M. (1999). "Natural selection on synonymous sites is correlated with gene length and recombination in Drosophila" . Genetics . 151 (1): 239–249. doi :10.1093/genetics/151.1.239 . PMC 1460462 . PMID 9872963 .
Ludwig, M. Z.; Patel, N. H.; Kreitman, M. (1998). "Functional analysis of eve stripe 2 enhancer evolution in Drosophila: Rules governing conservation and change". Development . 125 (5): 949–958. doi :10.1242/dev.125.5.949 . PMID 9449677 .