Mary Collins may refer to:

• Mary Collins (First Lady of Boston) (1920–2010)
• Mary Collins (politician) (born 1940), Canadian politician
• Mary Collins (missionary) (1846–1920), American who worked among the Sioux
• Mary Call Darby Collins (1911–2009), widow of governor LeRoy Collins and first lady of Florida, 1955–1961
• Mary Collins (immunologist), British immunologist at University College London
• Mary Collins (psychologist) (1895–1989), psychology lecturer at the University of Edinburgh
• Mary Teresa Collins, Irish Traveller abuse survivor and activist
• Mary Jean Collins (born 1939), American feminist
• Mary Lou Collins, a fictional character on the American television series The Larry Sanders Show
• Bo Derek (born Mary Cathleen Collins in 1956), American actress