Mathew is a masculine given name and a variant of Matthew. It is also used as a surname.

As a given name

Notable people with the given name include:

• Mat Erpelding (born 1975), American politician
• Mat Kearney (born 1978), American singer-songwriter
• Mat Latos (born 1987), American Major League Baseball pitcher
• Mat Mendenhall (born 1957), American former National Football League player
• Mathew Knowles (born 1952), record executive, band manager and father of Beyoncé and Solange
• Mat Osman (born 1967), English musician, bassist of the rock band Suede
• Mathew Leckie (born 1991), Australian footballer
• Mathew Martoma (born 1974), American hedge fund portfolio manager, convicted of insider trading
• Mathew Pitsch (born c. 1963), American businessman and politician
• Mathew Ryan (born 1992), Australian footballer
• Mathew Thompson (born 1982), Australian sports commentator and television presenter
• Mathew Barzal (born 1997), Canadian professional ice hockey centre
• Matt Willis (born 1983), English musician

As a surname

Notable people with the surname include:

• Annamma Mathew (1922–2003), chief editor of largest selling women's magazine in India, wife of K.M. Mathew
• Arnold Mathew (1852–1919), first Old Catholic bishop in the United Kingdom
• Bibin Mathew (born 1987), Indian track and field sprinter
• Biju Mathew, Indian-American activist
• Brian Mathew (born 1936), British botanist
• C. N. Saliya Mathew, 2nd Governor of Sabaragamuwa Province, Sri Lanka
• C. V. Mathew, Indian bishop
• Cyril Mathew (c.1912–1989), Sri Lankan politician and writer
• David Mathew (disambiguation)
• Edley Winston Mathew (1907-1978), Sri Lankan politician, Member of Parliament for Balangoda Electoral District
• Edward Mathew (British general) (1729–1805), fought in the American Revolutionary War
• Francis James Mathew, 2nd Earl Landaff (1768–1833), Irish politician
• Gervase Frederick Mathew (1842–1928), English naval officer and entomologist
• Harriet Mathew, 18th century London socialite and patron of the arts
• Hywel ap Syr Mathew (died 1581), Welsh poet, genealogist and soldier
• John Mathew (1849–1929), Australian Presbyterian minister and anthropologist
• K. K. Mathew 1911–1992), Indian Supreme Court judge
• K. M. Mathew (1917–2010), chief editor of leading Malayalam newspaper in Kerala, India
• KM Mathew, pen-name Ekalavyan, (1934–2012), Indian writer
• Karthika Mathew, Indian actress
• Kuzhivelil Mathew (born 1931), Indian biblical scholar
• Lazar Mathew, Indian medical academic
• Montague James Mathew (1773–1819), Irish politician and British Army general
• Nikhil Mathew (born 1984), singer from Kerala, India
• Oommen Mathew (1939–2013), Indian politician
• Ray Mathew (1929–2002), Australian author
• Rebekka Mathew (born 1986), Danish pop singer
• Robert Mathew (1911–1966), British Barrister and politician
• Sarah Mathew (c. 1805–1890), New Zealand diarist
• Simon Mathew (born 1984), Danish pop singer
• Suleka Mathew, Canadian actress
• Sushanth Mathew (born 1981), Indian football player
• Theobald Mathew (disambiguation)
• M. Thomas Mathew (born 1940), Indian literary critic
• Trevin Mathew (born 1978), Sri Lankan cricketer