May 21 - Eastern Orthodox Church calendar - May 23

All fixed commemorations below celebrated on June 4 by Orthodox Churches on the Old Calendar.^{[note 1]}

For May 22nd, Orthodox Churches on the Old Calendar commemorate the Saints listed on May 9.

Feasts

• Commemoration of the Holy Fathers of the Second Ecumenical Council (381)^[1][2]

Saints

• Righteous Melchizedek, King of Salem (ancient Jerusalem) (c. 2000 BC)^{[1][note 2]}
• Martyr Sophia the Healer.^[4]
• Martyr Marcellus, by being placed in molten lead.^[5]
• Martyr Codratus (Quadratus), by being dragged by horses.^[6]
• Martyr Basiliscus of Kamani (c. 285-305)^[7][8]
• Saint Donatus of Thmuis, Bishop and Martyr (316)^{[9][note 3]}
• Saint John Vladimir, King of Serbia, Martyr, Wonderworker (1015)^[1][10]

Pre-Schism Western saints

• Saint Ausonius, first Bishop of Angoulême (1st or 3rd century)^{[11][note 4]}
• Saint Marcian of Ravenna, Bishop and Confessor (c. 127)^{[8][12][note 5]}
• Martyrs Castus and Emilius, by fire, in Carthage (250)^[8][13]
• Martyrs Timothy, Faustinus and Venustus, in Rome, under Julian the Apostate (362)^[8][14]
• Saint Helen of Carnarvon (Elen Luyddog, Helen of Caernarfon), Princess, a late 4th-century founder of churches in Wales, and wife of Emperor Magnus Clemens Maximus (383-388)^[15]
• Saint Helen of Auxerre (c. 418)^{[8][16][note 6]}
• Saint Julia of Corsica the martyr, who was crucified (5th century)^[8][17]
• Saint Quiteria the virgin-martyr, in Spain (5th century)^[8][18]
• Saint Romanus of Subiaco (Romanus of Auxerre), ascetic who ministered to Saint Benedict of Nursia (560)^[8][19]
• Saint Fulk (c. 600)^[20]
• Saint Boethian of Pierrepont (near Laon), Irish, Benedictine monk, martyred in France (7th century)^[21]
• Saint Conall (Conald, Coel), of Inniskeel (Inniscoel, Innis-coel), County Donegal, Abbot of the island monastery of Inniskeel, where there is a holy well dedicated to him (7th century)^[22]
• Saint John of Parma, abbot of Saint John's at Parma from 973 to c. 982, then under Cluniac observance (c. 982)^{[20][note 7]}
• Saint Bobo (Beuvon), hermit (c. 985)^[20]

Post-Schism Orthodox saints

• Saint Kali of Asia Minor (c. 14th century)^{[23][note 8]}
• New Hieromartyr Zachariah of Prussa (1802)^[24]
• Blessed James, youth, of Borovichi (Novgorod), Wonderworker (1540)^{[1][25][note 9]}
• New Martyr Demetrios of Peloponnesos (1803)^{[26][note 10]}
• Venerable Monk-martyr Paul of Mt. Athos, at Tripolis, Peloponnesus (1818)^[1][28]

New martyrs and confessors

• New Hieromartyr Michael Borisov, priest (1942)^[29][30]

Other commemorations

• Synaxis of the Cyprus Icon ("Sophianois" Icon) of the Most Holy Mother of God.^{[31][32][note 11]}
• Repose of Cleopas of Valaam, disciple of Saint Paisius Velichkovsky (1816)^[33][34]
• Repose of Eldress Macrina of Volos (1995)^[1]

Icon gallery

• 
  The First Council of Constantinople (381), wall painting at the church of Stavropoleos, Bucharest, Romania.
• 
  First Ecumenical Council of Constantinople (381).
• 
  Abraham meets Melchisedech (Mosaic in Basilica di San Marco).
• 
  Mosaic of Melchisedech, Abraham and Abel (Ravenna - Basilica of Sant'Apollinare in Classe).
• 
  Icon of Melchizedek, in Libotin wooden church, Maramureș, Romania.
• 
  St. Jovan Vladimir.
• 
  St. Jovan Vladimir, from the Ardenica Monastery in Albania (1739).
• 
  Stained glass windows of Saint Julia of Corsica.
• 
  Virgin Martyr Saint Quiteria.