Mayo River Tributary to Dan River
Mayo River at US 220 access
Location of Mayo River mouth Show map of North Carolina Mayo River (Dan River tributary) (the United States) Show map of the United States
Location
Country	United States
State	North Carolina
County	Rockingham
City	Mayodan
Physical characteristics
Source	confluence of North and South Mayo Rivers
• location	about 6 miles northeast of Ayersville, North Carolina
• coordinates	36°32′25″N 078°59′21″W / 36.54028°N 78.98917°W / 36.54028; -78.98917[1]
• elevation	698 ft (213 m)[2]
Mouth	Dan River
• location	Madison, North Carolina
• coordinates	36°23′24″N 078°57′07″W / 36.39000°N 78.95194°W / 36.39000; -78.95194[1]
• elevation	538 ft (164 m)[2]
Length	15.58 mi (25.07 km)[3]
Basin size	317.50 square miles (822.3 km2)[4]
Discharge
• location	Mayodan River
• average	416.64 cu ft/s (11.798 m3/s) at mouth with Dan River[4]
Basin features
Progression	south-southeast
River system	Dan River
Tributaries
• left	Buffalo Creek Hickory Creek
• right	Pawpaw Creek
Bridges	Anglin Mill Road, T. Clarence Stone Highway, US 220, JJ Webster Highway, Dan Valley Road

The Mayo River is a tributary of the Dan River, which in turn is a tributary of the Roanoke River. All three rivers flow through the U.S. states of Virginia and North Carolina. It is named for Major William Mayo (ca. 1685-1744).

Course

The Mayo River is formed by two main branches, the North Fork Mayo River and the South Fork Mayo River. Both forks rise in Patrick County, Virginia, gathering the waters of many tributary streams. The two forks join in northwestern Rockingham County, North Carolina, forming the Mayo River proper, which then flows south into joining the Dan River near the towns of Mayodan, North Carolina and Madison, North Carolina.