Autosomal dominantA 50/50 chance of inheritance.Sickle-cell disease is inherited in the autosomal recessive pattern. When both parents have sickle-cell trait (carrier), a child has a 25% chance of sickle-cell disease (red icon), 25% do not carry any sickle-cell alleles (blue icon), and 50% have the heterozygous (carrier) condition.[1]If one parent has sickle-cell anaemia and the other has sickle-cell trait, then the child has a 50% chance of having sickle-cell disease and a 50% chance of having sickle-cell trait.[1]An example of the codominant inheritance of some of the four blood groups.
Mendelian traits in humans are human traits that are substantially influenced by Mendelian inheritance. Most – if not all – Mendelian traits are also influenced by other genes, the environment, immune responses, and chance. Therefore no trait is purely Mendelian, but many traits are almost entirely Mendelian, including canonical examples, such as those listed below. Purely Mendelian traits are a minority of all traits, since most phenotypic traits exhibit incomplete dominance, codominance, and contributions from many genes. If a trait is genetically influenced, but not well characterized by Mendelian inheritance, it is non-Mendelian.
^Hollfelder N, Babiker H, Granehäll L, Schlebusch CM, Jakobsson M (April 2020). "The genetic variation of lactase persistence alleles in northeast Africa". bioRxiv10.1101/2020.04.23.057356.
^McDonald JH (16 September 2013). "Earwax". Myths of Human Genetics. Baltimore: Sparky House Publishing.
