Mihailo (Serbian Cyrillic: Михаило)^{[pronunciation?]} is a South Slavic masculine given name. It is a variant of the Hebrew name Michael, and its cognates include Mihajlo and Mijailo. Common as a given name among Serbs, it is an uncommon surname.

Notable people with the name include:

• Mihailo Vojislavljević (fl. 1050–d. 1081)), King of Duklja
• Mihailo Ovčarević (fl. 1550–79), Habsburg Serb commander
• Mihailo Đurić (1925–2011), Serbian philosopher, retired professor, and academic
• Mihailo Janković (d. 1976), Serbian architect
• Mihailo Jovanović (b. 1975), Serbian footballer
• Mihailo Lalić (1914–1992), Montenegrin and Serbian novelist
• Mihailo Marković (1927-2010), Serbian philosopher
• Mihailo Merćep (1864–1937), Serb flight pioneer
• Mihailo Obrenović (1823–1868), Prince of Serbia
• Mihailo Petrović Alas (1868–1943), Serbian mathematician and inventor
• Mihailo Petrović (Chetnik) (1871-1941), Serbian archpriest and freedom fighter
• Mihailo Vukdragović (1900–1967), Serbian composer and conductor
• Miraš Dedeić or Metropolitan Mihailo (b. 1938), head of the uncanonical Montenegrin Orthodox Church
• Mihailo Tolotos (1855/1856-1938), Greek monk who lived 82 years not seeing a woman