Mike or Michael Reilly may refer to:

Politics

• Michael Reilly (Wisconsin politician) (1869–1944), member of the U.S. House of Representatives from Wisconsin's 6th district
• Michael Reilly (New York politician) (born 1973), member of the New York State Assembly for the 62nd District

Sports

Gridiron football

• Mike Reilly (1960s linebacker) (1942–2019), American football linebacker
• Mike Reilly (1980s linebacker) (born 1959), American football linebacker
• Michael Reilly (quarterback) (born 1985), American gridiron football quarterback
• Mike Reilly (coach) (1899–1971), American football, basketball, and baseball player and coach

Other sports

• Mike Reilly (umpire) (born 1949), Major League Baseball umpire
• Mike Reilly (golfer) (born 1968), American professional golfer
• Mike Reilly (ice hockey) (born 1993), American ice hockey defenseman

Other

• Mike Reilly (television personality)
• Michael Reilly (character), a character in the Australian police drama Water Rats