Minimal instruction set computer ( MISC) is a central processing unit (CPU) architecture, usually in the form of a microprocessor, with a very small number of basic operations and corresponding opcodes, together forming an instruction set. Such sets are commonly stack-based rather than register-based to reduce the size of operand specifiers.
stack machine architecture is inherently simpler since all instructions operate on the top-most stack entries.
One result of the stack architecture is an overall smaller instruction set, allowing a smaller and faster instruction decode unit with overall faster operation of individual instructions.
Characteristics and design philosophy
Separate from the stack definition of a MISC architecture, is the MISC architecture being defined by the number of instructions supported.
Typically a minimal instruction set computer is viewed as having 32 or fewer instructions,
   where NOP, RESET, and  CPUID type instructions are usually not counted by consensus due to their fundamental nature. 32 instructions is viewed as the highest allowable number of instructions for a MISC, though 16 or 8 instructions are closer to what is meant by "Minimal Instructions".
A MISC CPU cannot have zero instructions as that is a
zero instruction set computer. A MISC CPU cannot have one instruction as that is a
one instruction set computer.  The implemented CPU instructions should by default not support a wide set of inputs, so this typically means an 8-bit or 16-bit CPU.
If a CPU has an
NX bit, it is more likely to be viewed as being a complex instruction set computer (CISC) or reduced instruction set computer (RISC). MISC chips typically lack hardware memory protection of any kind, unless there is an application specific reason to have the feature.
If a CPU has a
microcode subsystem, that excludes it from being a MISC. The only
addressing mode considered acceptable [ for a MISC CPU to have is ] – by whom? Discuss load/store, the same as for reduced instruction set computer (RISC) CPUs. MISC CPUs can typically have between 64 KB to 4 GB of accessible addressable memory—but most MISC designs are under 1 megabyte.
Also, the instruction pipelines of MISC as a rule tend to be very simple.
Instruction pipelines, branch prediction, out-of-order execution, register renaming, and speculative execution broadly exclude a CPU from being classified as a MISC architecture.
1-bit CPUs are otherwise obsolete (and were not MISCs nor OISCs), the first carbon nanotube computer is a 1-bit one-instruction set computer, and has only 178 transistors, and thus likely the lowest-complexity (or next-lowest) CPU produced so far (by transistor count).
Some of the first digital computers implemented with instruction sets were by modern definition minimal instruction set computers.
Among these various computers, only ILLIAC and ORDVAC had compatible instruction sets.
Manchester Baby (University of Manchester, England) made its first successful run of a stored program on June 21, 1948.
Electronic Delay Storage Automatic Calculator (EDSAC, University of Cambridge, England) was the first practical stored-program electronic computer (May 1949)
Manchester Mark 1 ( Victoria University of Manchester, England) Developed from the Baby (June 1949) Commonwealth Scientific and Industrial Research Automatic Computer (
CSIRAC, Council for Scientific and Industrial Research) Australia (November 1949) Electronic Discrete Variable Automatic Computer (
EDVAC, Ballistic Research Laboratory, Computing Laboratory at Aberdeen Proving Ground 1951) Ordnance Discrete Variable Automatic Computer (
ORDVAC, University of Illinois at Urbana–Champaign) at Aberdeen Proving Ground, Maryland (completed November 1951) 
IAS machine at Princeton University (January 1952)
MANIAC I at Los Alamos Scientific Laboratory (March 1952)
MESM performed its first test run in Kyiv on November 6, 1950 Illinois Automatic Computer ( ILLIAC) at the University of Illinois, (September 1952)
Early stored-program computers
IBM SSEC had the ability to treat instructions as data, and was publicly demonstrated on January 27, 1948. This ability was claimed in a US patent issued April 28, 1953. However, it was partly electromechanical, not fully electronic. In practice, instructions were read from paper tape due to its limited memory.   The
Manchester Baby, by the Victoria University of Manchester, was the first fully electronic computer to run a stored program. It ran a factoring program for 52 minutes on June 21, 1948, after running a simple division program and a program to show that two numbers were relatively prime. The Electronic Numerical Integrator and Computer (
ENIAC) was modified to run as a primitive read-only stored-program computer (using the Function Tables for program read-only memory (ROM) and was demonstrated as such on September 16, 1948, running a program by Adele Goldstine for von Neumann. The Binary Automatic Computer (
BINAC) ran some test programs in February, March, and April 1949, although was not completed until September 1949. The
Manchester Mark 1 developed from the Baby project. An intermediate version of the Mark 1 was available to run programs in April 1949, but was not completed until October 1949. The
Electronic Delay Storage Automatic Calculator (EDSAC) ran its first program on May 6, 1949. The Electronic Discrete Variable Automatic Computer (
EDVAC) was delivered in August 1949, but it had problems that kept it from being put into regular operation until 1951. The Commonwealth Scientific and Industrial Research Automatic Computer (
CSIRAC, formerly CSIR Mk I) ran its first program in November 1949. The Standards Eastern Automatic Computer (
SEAC) was demonstrated in April 1950. The
Pilot ACE ran its first program on May 10, 1950 and was demonstrated in December 1950. The Standards Western Automatic Computer (
SWAC) was completed in July 1950. The
Whirlwind was completed in December 1950 and was in actual use in April 1951. The first ERA Atlas (later the commercial ERA 1101/UNIVAC 1101) was installed in December 1950.
The disadvantage of a MISC is that instructions tend to have more sequential dependencies, reducing overall
MISC architectures have much in common with some features of some
programming languages such as Forth's use of the stack, and the Java virtual machine. Both are weak in providing full instruction-level parallelism.
Probably the most commercially successful MISC was the original INMOS
transputer architecture that had no floating-point unit. However, many 8-bit microcontrollers, for embedded computer applications, qualify as MISC.
STEREO spacecraft includes two P24 MISC CPUs and two CPU24 MISC CPUs.